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Insulin - The Crooked Timber
Before the discovery of insulin, a diagnosis of Type 1 diabetes was a death sentence. One hundred years after a milestone medical discovery, 'Insulin - The Crooked Timber' tells the story of how insulin was transformed from what one clinician called 'thick brown muck' into the very first drug to be produced using genetic engineering, one which would earn the founders of the US biotech company Genentech a small fortune. Yet when Canadian doctor Frederick Banting was told in 1923 that he had won the Nobel Prize for this life-saving discovery, he was furious. For the prize had not been awarded to him alone - but jointly with a man whom he felt had no right to this honour. The human story behind...
The Man in the Monkeynut Coat
Sir Isaac Newton once declared that his momentous discoveries were only made thanks to having 'stood on the shoulders of giants'. The same might also be said of the scientists James Watson and Francis Crick. Their discovery of the structure of DNA was, without doubt, one of the biggest scientific landmarks in history and, thanks largely to the success of Watson's best-selling memoir 'The Double Helix', there might seem to be little new to say about this story. But much remains to be said about the particular 'giants' on whose shoulders Watson and Crick stood. Of these, the crystallographer Rosalind Franklin, whose famous X-ray diffraction photograph known as 'Photo 51' provided Watson and Cr...
The Man in the Monkeynut Coat
Sir Isaac Newton once declared that his momentous discoveries were only made thanks to having 'stood on the shoulders of giants'. The same might also be said of the scientists James Watson and Francis Crick. Their discovery of the structure of DNA was, without doubt, one of the biggest scientific landmarks in history and, thanks largely to the success of Watson's best-selling memoir 'The Double Helix', there might seem to be little new to say about this story. But much remains to be said about the particular 'giants' on whose shoulders Watson and Crick stood. Of these, the crystallographer Rosalind Franklin, whose famous X-ray diffraction photograph known as 'Photo 51' provided Watson and Cr...
The Discovery of Insulin
The discovery of insulin at the University of Toronto in 1921-22 was one of the most dramatic events in the history of the treatment of disease. Insulin was a wonder-drug with ability to bring patients back from the very brink of death, and it was no surprise that in 1923 the Nobel Prize for Medicine was awarded to its discoverers, the Canadian research team of Banting, Best, Collip, and Macleod. In this engaging and award-winning account, historian Michael Bliss recounts the fascinating story behind the discovery of insulin – a story as much filled with fiery confrontation and intense competition as medical dedication and scientific genius. Originally published in 1982 and updated in 1996, The Discovery of Insulin has won the City of Toronto Book Award, the Jason Hannah Medal of the Royal Society of Canada, and the William H. Welch Medal of the American Association for the History of Medicine.
The Urban Fact
The Urban Fact examines Aldo Rossis formulation of a theory of the city, developed over the period of roughly ten years, from Architecture of the City published in 1966, to Analogous City exhibited in 1976. Rossis theory is not taken as an abstract argument, but is seen through his work from that period. A careful selection of twenty-three projects is presented here at face value. These projects, bound by the reality of their setting, but also charged with cultural and civic ambition, illustrate the intricacy of an architectural project as a complex 'whole'. They also demonstrate how architecture could contribute to the changing urban context of the field, hinting at an oeuvre painfully aware of its limitations and stubborn in its intentions.
Decision Support Systems for Sustainable Development
In recent years, much work has been done in formulating and clarifying the concept of sustainable development and related theoretical and research issues. Now, the challenge has shifted to designing and stimulating processes of effective planning and decision-making, at all levels of human activity, in such a way as to achieve local and global sustainable development. Information technology can help a great deal in achieving sustainable development by providing well-designed and useful tools for decision makers. One such tool is the decision support system, or DSS. This book explores the area of DSS in the context of sustainable development. As DSS is a very new technique, especially in the ...
What is Life?
Seventy years ago, Erwin Schrödinger posed a profound question: 'What is life, and how did it emerge from non-life?' This problem has puzzled biologists and physical scientists ever since. Living things are hugely complex and have unique properties, such as self-maintenance and apparently purposeful behaviour which we do not see in inert matter. So how does chemistry give rise to biology? What could have led the first replicating molecules up such a path? Now, developments in the emerging field of 'systems chemistry' are unlocking the problem. Addy Pross shows how the different kind of stability that operates among replicating molecules results in a tendency for chemical systems to become m...
Cat Person
She thought, brightly, This is the worst life decision I have ever made! And she marvelled at herself for a while, at the mystery of this person who’d just done this bizarre, inexplicable thing. Margot meets Robert. They exchange numbers. They text, flirt and eventually have sex – the type of sex you attempt to forget. How could one date go so wrong? Everything that takes place in Cat Person happens to countless people every day. But Cat Person is not an everyday story. In less than a week, Kristen Roupenian’s New Yorker debut became the most read and shared short story in their website’s history. This is the bad date that went viral. This is the conversation we’re all having. This gift edition contains photographs by celebrated photographer Elinor Carucci, who was commissioned by the New Yorker to capture the image that accompanied Kristen Roupenian’s Cat Person when it appeared in the magazine. You Know You Want This, Kristen Roupenian’s debut collection, will be published in February 2019.
The Real Cost of Capital
"This book is required reading for anyone involved in the practical issues of cost of capital decisions. It is written in a way that engages the novice, and yet challenges the professional to rethink the real issues." Brendan Scholey, Bloomberg. The cost of capital is the fundamental financial tool for business decision-making. It drives measures of value creation and destruction, and forms the basis of financial analysis using cash flow and other frameworks. This book is here to help the business world to use the cost of capital for real. The Real Cost of Capital describes the key issues in understanding and using the cost of capital today, taking principles from the world of managerial fin...
Protein Structure and Function
Each title in the 'Primers in Biology' series is constructed on a modular principle that is intended to make them easy to teach from, to learn from, and to use for reference.
