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The purpose of this textbook is to meticulously depict all aspects of chest tumors in a comprehensive volume format that encompasses their biology, clinical presentation and management. It is the only book to do this. Chapters of specific interest have also been included to cover such wide-ranging topics as management of the elderly and chemoprevention, along with ethical, social and financial issues associated with such tumors. All participating authors, selected from an international panel of highly regarded scientists currently pioneering lung cancer research, are major contributors in the area of expertise they have been chosen to present.
Targeted Therapy for Cancer discusses the more archetypal systemic targeted therapies, such as those employing monoclonal antibodies or liposomes, but also includes strategies, such as photodynamic therapy and boron neutron capture therapy, that rely on direct physical targeting of disease. The explosion in our understanding of the molecular biology of cancer in recent years has led to the identification of a number of new potential therapeutic targets. This book brings together the very latest research in this field from an international group of experts and will prove invaluable for molecular oncologists, cancer researchers and those involved with clinical trials as well as providing a reference for oncologists who are beginning to use some of these therapies in everyday clinical practice.
Head and neck cancer (HNC) is a rapidly evolving field of medical science. Tremendous progress has been made over the past five decades in revealing the basic molecular biology involved in the disease process, developing and adopting more effective organ-preserving treatment protocols and refining surgical ablative and reconstructive approaches to facilitate functional restoration of patients without compromising survival. We now have a much clearer understanding of the disease, its management and the rehabilitation of patients. But there is still much to be done. This book aims to cover a range of exciting new findings in clinical sciences, basic sciences and allied specialties with an emph...
This second edition of an award winning title has been thoroughly updated by a team of world leading head and neck surgeons, oncologists and allied healthcare professionals. Principles and Practice of Head & Neck Surgery and Oncology, 2nd edition is a comprehensive evidence-based account of the current scientific knowledge about head and neck t
Despite significant progress in the treatment of head and neck cancer using new techniques, including organ preservation strategies, recurrence still occurs in up to 50% of patients with locally advanced disease. Head and Neck Cancer Recurrence is the first comprehensive, evidence-based reference on this complex condition, providing state-of-the-art strategies for treating and managing recurrence at each site within the head and neck. With this book at hand, specialists will have guidelines for detecting the presence of a tumor, evaluating the extent and likelihood of successful salvage, determining the most effective treatment modalities, and assessing the potential impact on outcome and fu...
In the last decade there has been an explosion of interest in viral therapies for cancer. Viral agents have been developed that are harmless to normal tissues but selectively able to kill cancer cells. These agents have been endowed with additional selectivity and potency through genetic manipulation. Increasingly these viruses are undergoing evaluation in clinical trials, both as single agents and in combination with standard chemotherapy and radiotherapy. This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range o...
Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laborat...
This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.