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Recently, stem cells have been drawing increasing interest in basic and translational research that aims to understand stem cell biology and generate new therapies for various disorders. Many stem cells can be cultured in 2D relatively easily using tissue culture plastic. However, many of these cultures do not represent the natural conditions of stem cells in the body. In the body, microenvironments include numerous supporting cells and molecules. Therefore, researchers and clinicians have sought ideal stem cell preparations for basic research and clinical applications, which may be attainable through 3D culture of stem cells. The 3D cultures mimic the conditions of the natural environment o...
A Hetek szakmai műhelye az elmúlt mintegy másfél évtizedben folyamatosan, szinte hétről hétre ráirányította olvasói figyelmét a zsidóság múltjára, jelenére és egyes írásaiban a jövőjére is. A kiadónk gondozásában megjelent könyvek között ugyancsak megtalálhatók a történelmi zsidósággal és a modern Izrael küzdelmevel foglalkozó művek. A holokauszt 70. évfordulója újabb alkalmat ad számunkra, hogy – ezúttal az ATV-vel karöltve – átfogó, érthető és feldolgozható ismeretanyagot adjunk az olvasó kezébe. Szerzőink olyan történészek, kutatók, egyetemi tanárok, tudósok, szakírók, akik mind hazai, mind pedig nemzetközi szinten ismert és elismert szakértői a holokausztnak. A kötetben a vészkorszak – elsősorban magyar vonatkozású – eseményei 12 témára bontva szerepelnek. Minden témakört egy túlélővel készült interjú zár, aki tanúságtételével hitelesíti az olvasottakat.
This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells. The book opens with a discussion of the evolution of research on tight junctions, discussing a range of primary areas of growth, including the current knowledge on the particular physiological function of different claudins due to the development of a...
An exploration of the Green Belt conservation project between the former East and West Germanies and its relationship to emergent ecosystems, trauma, and memorialization. The first book-length scholarly treatment of Germany’s largest conservation project, the Green Belt, Mnemonic Ecologies by Sonja Pieck presents a new interdisciplinary approach: that effective restoration and conservation of wounded land must merge ecology with memory. Since the Cold War’s end in 1989, German conservationists have transformed the once-militarized border between East and West Germany into an extensive protected area. Yet as forests, meadows, and wetlands replace fences, minefields, and guard towers, ecol...
In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.
The first comprehensive reference to invertebrate histology Invertebrate Histology is a groundbreaking text that offers a comprehensive review of histology in invertebrates. Designed for use by anyone studying, diagnosing, or researching invertebrates, the book covers all major taxonomic groups with details of the histologic features, with color photographs and drawings that clearly demonstrate gross anatomy and histology. The authors, who are each experts in the histology of their respective taxa, bring together the most recent information on the topic into a single, complete volume. An accessible resource, each chapter focuses on a single taxonomic group with salient gross and histologic f...
During the Nazi era, about three million Jews – half the victims of the Holocaust – were deported from the German Reich, the occupied territories, as well as Nazi-allied countries, and sent to ghettos, camps, and extermination centers. The police and the SS also deported tens of thousands of Sinti and Roma, mainly to the Auschwitz concentration and extermination camp, where most of them were killed. Deportations were central to National Socialist persecution and extermination. In November 2020, an international conference organized by the Arolsen Archives focused on the various historical sources, their research potential, and (digital) methods of cataloging them. It also explored new (systematizing and comparative) approaches in historical research. This volume features over 20 contributions by scholars from different countries and with a variety of perspectives and questions. The main geographical focus is on deportations from the German Reich and German-occupied Southeastern Europe.
This atlas presents the basic concepts and principles of functional animal anatomy and histology thereby furthering our understanding of evolutionary concepts and adaptation to the environment. It provides a step-by-step dissection guide with numerous colour photographs of the animals featured. It also presents images of the major organs along with histological sections of those organs. A wide range of interactive tutorials gives readers the opportunity to evaluate their understanding of the basic anatomy and histology of the organs of the animals presented.
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