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A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book...
Effective administration of government and governmental organizations is a crucial part of achieving success in those organizations. To develop and implement best practices, policymakers and leaders must first understand the fundamental tenants and recent advances in public administration. Public Affairs and Administration: Concepts, Methodologies, Tools, and Applications explores the concept of governmental management, public policy, and politics at all levels of organizational governance. With chapters on topics ranging from privacy and surveillance to the impact of new media on political participation, this multi-volume reference work is an important resource for policymakers, government officials, and academicians and students of political science.
Crop improvement using classically induced mutagenesis is now well standardized. Many new promising varieties of different crops have been successfully developed worldwide using both physical and chemical mutagens. Voluminous literature is now available on basic and applied aspects of mutagenesis. The mutation technique has been refined and holds the promise of generating much wider and more desirable variability than classical breeding. Recent advances in technology combined with classical mutation breeding offer new and exciting challenges for the development of new varieties. A global inventory of induced mutagenesis activities for crop improvement is requried. This book covers both basic...
Set includes revised editions of some issues.
This book comprises select proceedings of the international conference ETAEERE 2020, and primarily focuses on renewable energy resources and smart grid technologies. The book provides valuable information on the technology and design of power grid integration on microgrids of green energy sources. Some of the topics covered include solar PV array, hybrid microgrid, daylight harvesting, green computing, photovoltaic applications, nanogrid applications, AC/DC/AC converter for wind energy systems, solar photovoltaic panels, PEM fuel cell system, and biogas run dual-fueled diesel engine. The contents of this book will be useful for researchers and practitioners working in the areas of smart grids and renewable energy generation, distribution, and management.
Heart attack (ischaemic heart disease or coronary heart disease) as one of a group of cardiovascular diseases, is one of the main causes of death (over 30 million/year) in the developed and developing world. The dual aim of this book is to review the well-established risk factors in CHD and to look forward to disease prevention, equipped with lessons from the past. The book covers etiology to public health, including studies within a single population and international studies, important areas of methodological development, trials to test preventive strategies, and the application of epidemiological and other knowledge to the development of public health policy for the prevention of widespread disease. It is an all-encompassing work containing contributions from the world authorities in the field.
The present book consist of 30 reviews on important pest and diseases of cash, cereals, oilseed, vegetables, fodders, fruits and pulses etc. Most of these articles have been prepared by authorities in their receptive areas. There is worldwide swing to the use of ecologically safe, environment friendly methods of protecting crops from pests and pathogens.
This is the sixteenth annual volume of Progress in Heterocyclic Chemistry, and covers the literature published during 2003 on most of the important heterocyclic ring systems.This volume opens with two specialized reviews. The first covers 'Lamellarins: Isolation, activity and synthesis' a significant group of biologically active marine alkaloids and the second discusses 'Radical Additions to Pyridines, Quinolines and Isoquinolines'. The remaining chapters examine the recent literature on the common heterocycles in order of increasing ring size and the heteroatoms present.
Traditionally, livestock manure has been used to provide nutrients for plant growth and to improve soil conditions. However, the increase in concentrated animal feeding operations (CAFOs) results in high levels of plant nutrients, such as nitrogen and phosphorus, in the proximal crop and pasturelands as a result of applying more manure than what is required to meet the local plant nutrient demand. Soil runoff and leaching of land-applied manure can enrich the surface and ground water with nitrogen and phosphorus, leading to eutrophication and hypoxia. In addition, overapplication of animal manure contributes to pathogen spread, the release of hormones and other pharmaceutically active compounds, and the emission of ammonia, greenhouse gases, and odorous compounds. In this Special Issue, we present 11 interesting articles covering the production of renewable energy and fuels, extraction of ammonia from animal manure, the agricultural and environmental benefits of using animal manure or its derived materials such as biochar or ashes, and the difference in microbial communities and pathogen survival after anaerobic lagoon treatment.
Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discov...