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The Chemistry of Mycotoxins
The biological activity of mycotoxins ranges from weak and/or sometimes positive effects, such as antibacterial activity (see penicillin derivatives derived from Penicillium strains) to strong mutagenic (e. g. aflatoxins, patulin), carcinogenic (e. g. aflatoxins), teratogenic, neurotoxic (e. g. ochratoxins), nephrotoxic (e. g. fumonisins, citrinin), hepatotoxic, and immunotoxic (e. g. ochratoxins, diketopiperazines) activity. Nowadays, many laboratories around the world are specialized in the detection of mycotoxins in food products and contaminated material found in housing. In this volume, a focus on the most important classes of mycotoxins is provided and their chemistry of the last ten years is discussed. In each Section, the individual biological impact is outlined. Sections are arranged according to mycotoxin classes (e. g. aflatoxins) and/or structural classes (e. g. resorcinyl lactones, diketopiperazines). The biology of mycotoxins is also described.
Privileged Scaffolds in Medicinal Chemistry
This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.
Sulfonyl Ynamides as Useful Tools for N-Heterocyclic Chemistry
Sulfonyl ynamides are highly versatile and synthetically useful reagents. This thesis details the modular synthesis and use of sulfonyl ynamides in order to access N-heterocyclic scaffolds, such as quinolines and pyrazoles. The synthesis of a wide array of sulfonyl ynamides can be realized via copper-catalyzed amidative cross-couplings or by elimination of dichloroenamide precursors. Additionally the use of Sonogashira chemistry to further diversify terminal ynamides and the synthesis of solid-supported ynamides was investigated. Electrophilically-activated amides can be reacted with sulfonyl ynamides in order to access highly functionalized 4-aminoquinolines. The straightforward amide activ...
Archaeology and Ancient Religion in the American Midcontinent
Analyses of big datasets signal important directions for the archaeology of religion in the Archaic to Mississippian Native North America Across North America, huge data accumulations derived from decades of cultural resource management studies, combined with old museum collections, provide archaeologists with unparalleled opportunities to explore new questions about the lives of ancient native peoples. For many years the topics of technology, economy, and political organization have received the most research attention, while ritual, religion, and symbolic expression have largely been ignored. This was often the case because researchers considered such topics beyond reach of their methods a...
The Anomeric Effect
This book provides a comprehensive review of the structural, conformational, and chemical manifestations of the anomeric effect. In order to present a cogent discussion of this most fundamental and relevant phenomenon, three chapters examine our present understanding of the origin of this conformational effect, based upon a wealth of theoretical and physical data. Equally important, however, are three additional chapters that deal with the general consequences of the stereoelectronic interactions that are associated with the basis of the anomeric effect. The remainder of the book is devoted to new areas of development in the topic-such as differentiation of the endo and exo anomeric interactions, specific analysis of the enthalpic component of anomeric effects, critical evaluation of the kinetics and reverse anomeric effects, discovery of a new substantial effect in second- and lower-row anomeric segments, and others.
Korea
Compiled by specialists from the University of Durham Department of East Asian Studies, this new reference work contains approximately 1500 entries covering Korean civilisation from early times to the present day. Subjects include history, politics, art, archaeology, literature, etc. The Dictionary is intended for students, teachers and researchers, and will also be of interest to the general reader. Entries provide factual information and contain suggestions for further reading. A name index and comprehensive cross-reference system make this an easy to use, multi-purpose guide for the student of Korea in the broadest sense.
Old Glasgow Weavers
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Methodologies in Amine Synthesis
Discover a comprehensive overview of efficient synthetic routes to an important compound class in organic and pharmaceutical chemistry Methodologies in Amine Synthesis: Challenges and Applications delivers powerful and state-of-the-art methods for the efficient preparation of amines. The text summarizes recent advances in the electrophilic amination reaction, hydroamination, C-H amination and newly developed photocatalytic approaches. The distinguished editor has included resources that discuss organocatalytic and enzymatic routes to the generation of amines under mild and environmentally friendly conditions. The book also highlights the relevance of the amino function in bioactive molecules...
English Surnames
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The Canon
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