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This book integrates discoveries from recent years to show the diversity of molecular mechanisms that contribute to memory consolidation, reconsolidation, extinction, and forgetting. It provides a special focus on the processes that govern functional and structural plasticity of dendritic spines. In nine chapters, new and important ideas related to learning and memory processes will be presented. Themes discussed include the role of AMPA receptors in memory, two signalling cascades involved in local spine remodelling and memory, the role of extracellular matrix proteins in memory, the regulation of gene expression and protein translation, and mechanisms of retrieval-induced memory modulation and forgetting. We believe that the study of these topics represents a great step toward understanding the complexity of the brain and the processes it governs.
This volume looks at the associative mechanisms of the brain, particularly of the cortico-limbic and diencephalic systems, and also at the macromolecular effects on them, by integrating the contributions of various disciplines converging on one subject and from different points of view. It addresses the question of how so many different activity levels — the biochemical, physiological, and psychological ones — interact in integrative processes. The topics treated include brain reverberating systems and associative phenomena; long-term potentiation, learning, and memory; gene activity and brain activity; and gene expression and information processing during sleep.
This interdisciplinary work discloses an unexpected coherence between recent concepts in brain science and postmodern thought. A nonlinear dynamical model of brain states is viewed as an autopoietic, autorhoetic, self-organizing, self-tuning eruption under multiple constraints and guided by an overarching optimization principle which insures conservation of invariances and enhancement of symmetries. The nonlinear dynamical brain as developed shows quantum nonlocality, undergoes chaotic regimes, and does not compute. Heidegger and Derrida are appropriated as dynamical theorists who are concerned respectively with the movement of time and being ("Ereignis") and text ("Differance"). The chasm between postmodern thought and the thoroughly metaphysical theory that the brain computes is breached, once the nonlinear dynamical framework is adopted. The book is written in a postmodern style, making playful, opportunistic use of marginalia and dreams, and presenting a nonserial surface of broken complexity. (Series A)
That molecular neurobiology has become a dominant part of neuroscience research can be credited to the discovery of inducible gene expression in the brain and spinal cord. This volume deals with genes, whose expression patterns in the vertebrate central nervous system were the first to be revealed and then the most extensively investigated over the last 15 years. Immediate early genes (IEG) and their protein products, especially those acting as regulators of transcription (inducible transcription factors, ITF) have proven to be very valuable tools in functional neuroanatomy and neurophysiology, as they are rapidly and transiently induced in specific neurons in response to various modes of st...
This book deals primarily with the role of emotions in the mechanisms of memory. It is a compilation of the lectures given at a course conducted at the International School of Biocybernetics.
The new experimental tools and approaches of modern biology have allowed us to better understand many fundamental properties of the eukaryotic cells. These significant discoveries have drastically changed the diagnostic and therapeutic approaches of modern clinical practice. On April 18-22, 1988, an International Symposium on Cell Function and Disease was held in Monterrey, Nuevo Leon, Mexico, aimed at reviewing some of the most recent advances made in the following five areas: Genes and Human Diseases; Cellular and Molecular Pathology; Infectious Diseases; Brain Transplants and the New Approaches and Techniques with Potential Application to Cell Function and Disease. This book is based on t...
This volume analyses ancient and medieval theories of intentionality in various contexts: perception, imagination, and intellectual thinking. It sheds new light on classical theories (e.g. by Aristotle and Thomas Aquinas) and examines neglected sources, both Greek and Latin. It includes contributions by J. Biard, M. Burnyeat, V. Caston, D. Frede, R. Gaskin, E. Karger, C. Michon, D. O'Meara, C. Panaccio, R. Pasnau, D. Perler, Ch. Rapp, P. Simons, R. Sorabji, and H. Weidemann.
This book is unique in that it brings together in one place an account of recent advances in our understanding of the biology of dyslexia. It grew out of a Rodin Remediation Foundation International conference held on this topic in Boulder, Colorado in 1990, which included most of the world's experts on the genetics and neurology of dyslexia. Ten years ago a volume on this topic would scarcely been possible, and now we have an emerging, comprehensive neuroscientific understanding of this complex behavioral disorder that goes from genes to brain to behavior. Building on recent advances in the understanding of the cognitive phenotype of dyslexia, these authors present new data on both the etio...
Advances in Heterocyclic Chemistry