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Thalassemia Syndromes
The thalassemia syndromes are a diverse group of hereditary anemias caused by decreased or absent production of one type of globin chain. Genetic counseling, prenatal diagnosis, and newborn screening are all issues of importance in these inherited disorders. This book provides a comprehensive overview of thalassemia, including information on its mechanisms and treatment modalities. Chapters elucidate the mechanism of disordered synthesis of hemoglobin in thalassemia and present recent studies of the genetic mechanisms that underlie this abnormal biosynthetic process.
Neuroblastoma
Neuroblastoma (NBL) is the most common extracranial solid tumor of childhood, with about 700 new cases of neuroblastoma seen each year in the United States. The 5-year survival rate for children with high-risk NBL is only 50-60%, and this survival rate has not improved over the last 10 years. High-risk patients receive multimodality treatment, including chemotherapy, surgery, radiation therapy, biologic therapy and immunotherapy, all of which are associated with significant morbidity. Recent years have seen many advances in treatment of neuroblastoma, including therapeutic MIBG, immunotherapy, and personalized targeted therapy based on the genetic alterations seen in the tumor. The primary o...
Epidemiology of Communicable and Non-Communicable Diseases
Human sufferings, including deaths, can be reduced or avoided by applying routine principles of hygiene in individuals' lives. Some hygiene routines are purely simple remedies, which are inexpensive, affordable, acceptable and easily accessible. It is evident that change is first enacted from within the mindset of an individual, then transmitted to families, groups and communities, and eventually the mindset of a nation can change creating an environment which is better for everybody to live in. This book contains chapters discussing conditions or diseases that may not be common in the readers' area. Caution as such may never be underestimated considering the fact that we are living in a global village where one can never say 'this does not occur in my area' but rather question, does this occur in my community, why does it occur, who is affected, where and when does it occur and what can be done about it? These questions constitute what epidemiology is all about, and their precise and comprehensive answers can transform lives and help us have the right perceptions for the health challenges we face and accept the possibility of dealing with them directly.
Laila
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Out from the Shadow of Men
"The shadow of a man is better than a roof over the head." This Arabic proverb has long described the plight of women in Egypt. Like the classic Pyramids of Giza, the culture of Egypt for the most part stands unchanged. Egyptian men continue to use the banner of Islam and antiquated interpretation of the Quran to justify controlling women. Egyptian women continue to believe God has ordered men to do so. Yet Laila El-Sissi broke the pattern. Forty years ago, when Laila, a shy and malleable 15-year-old, and her more rebellious 16-year-old sister Rawyia learn that they are betrothed to men they have never met, they refuse to live in the prison constructed by their society, hoping for a better l...
Laila
Although the Arabic world is as diverse as any other region, customs and traditions endure. Injustices continue. And then there is Laila. Trapped in a marriage to a man she finds physically revolting, Laila begins to realize secret truths about her sexuality, about her very identity as a modern Jordanian woman. "Good" Arab women may have occasional lurid fantasies about dominating men in bed... but Laila actually finds the strength to do it. And when she dies suddenly in an encounter with a lover, the stakes for the survivors become a matter of life and death. In Laila, Fadi Zaghmout gives voice to the Arab woman to put men in her society on trial.
Secret Son
When a young man is given the chance to rewrite his future, he doesn't realize the price he will pay for giving up his past... Casablanca's stinking alleys are the only home that nineteen-year-old Youssef El-Mekki has ever known. Raised by his mother in a one-room home, the film stars flickering on the local cinema's screen offer the only glimmer of hope to his frustrated dreams of escape. Until, that is, the father he thought dead turns out to be very much alive. A high profile businessman with wealth to burn, Nabil is disenchanted with his daughter and eager to take in the boy he never knew. Soon Youssef is installed in his penthouse and sampling the gold-plated luxuries enjoyed by Casablanca's elite. But as he leaves the slums of his childhood behind him, he comes up against a starkly un-glittering reality...
Laila and the Sands of Time
Thirteen-year-old Laila, still grieving over her father's death, goes on their planned pilgrimage with her aunt and uncle. When she is transported back in time to 7th century Arabia, she faces the dangers of the desert, takes on a disguise, and saves a baby's life. But will she ever return to her own time?
Leila and the Madman
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