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Proton Pump Inhibitors
Inhibition of the proton pump in the parietal cells has been established as the main therapeutic principle in the treatment of acid-related diseases, such as peptic ulcer and gastro-oesophageal reflux. The proton pump inhi bitors are tailored for their purpose. They accumulate in the target cell, are activated by acid and bind strongly to the specific target - the proton pump. The clinical superiority of the proton pump inhibitors is due not only to their high efficacy but also to the long duration of the acid inhibition in comparison with other antisecretory drugs. At present when drug discovery mostly relies on identification and characterization of potential targets by genome research, molecular biology, combinatorial chemistry and automated screening, it seems worthwhile to present the development of the tITst proton pump inhibitor - omeprazol- starting from a chemical structure with an observed antisecretory effect but also severe toxic effects that had to be eliminated. As always, basic and applied research operate luind in hand to optimize the delicate balance be tween efficacy and safety of a new drug. This goal often involves time and many different specialists.
Medifocus Guidebook On: Gastroesophageal Reflux Disease
The MediFocus Guidebook on Gastroesophageal Reflux Disease is the most comprehensive, up-to-date source of information available. You will get answers to your questions, including risk factors of Gastroesophageal Reflux Disease, standard and alternative treatment options, leading doctors, hospitals and medical centers that specialize in Gastroesophageal Reflux Disease, results of the latest clinical trials, support groups and additional resources, and promising new treatments on the horizon. This one of a kind Guidebook offers answers to your critical health questions including the latest treatments, clinical trials, and expert research; high quality, professional level information you can trust and understand culled from the latest peer-reviewed journals; and a unique resource to find leading experts, institutions, and support organizations including contact information and hyperlinks. This Guidebook was updated on January 24, 2012.
Antireflux Surgery
This volume provides a comprehensive, state-of-the-art overview of the major issues specific to the field of antireflux surgery. It provides exceptional instructional detail regarding performance of antireflux surgery from leading esophageal surgeons around the world. This volume represents the only resource of its kind dedicated specifically to the issues unique to antireflux surgery. It is rich in detail and helpful illustrations that instruct surgeons in proper technique as well as presenting the reasoning behind various techniques. Written by experts in the field, Antireflux Surgery is of great value to practicing surgeons who perform gastrointestinal surgery, medical students, surgical residents, and fellows.
Kierkegaard's Influence on Literature, Criticism and Art
Vol. 2 is dedicated to the use of Kierkegaard by later Danish writers. Almost from the beginning Kierkegaard's works were standard reading for these authors. Danish novelists and critics from the Modern Breakthrough movement in the 1870s were among the first to make extensive use of his writings. These included the theoretical leader of the movement, the critic Georg Brandes, who wrote an entire book on Kierkegaard, and the novelists Jens Peter Jacobsen and Henrik Pontoppidan
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Update Gastroenterology 2006
Drug-induced mucosal damage is of immense importance in gastroenterology. It is imperative that clinicians understand how these lesions come about, what the sometimes devastating consequences are and what can be done to prevent or to treat such calamities. Drug-induced damage is bound to increase in the future as the population ages and polypharmacy becomes the rule instead of the exception. Hopes for improvement were shattered when the long term consequences of COX-2 inhibition became available. Is the COX-1/COX-2 concept truly obsolete? Several issues are discussed by European experts in the second part of the book. What the clinician should know about non acid, weakly acid or biliary reflux is discussed in depth. Novel developments of gastrointestinal neuropathies and motor disorders concentrate on IBS, pseudo-obstruction and faecal incontinence. Our surgical colleagues will certainly be interested in novel minimally invasive procedures. Finally all will learn from a critical analysis of novel diagnostic imaging modalities.
Lars Ahlin
None
Update Gastroenterology 2003
John Libbey Eurotext continues to publish the proceedings of the gastroenterology seminars taught by leading European specialists and organised by the European Association for Gastroenterology and Endoscopy (EAGE). The aim of the book is to describe major clinical and therapeutic progress observed during 2003.
