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Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived from ingested alcohol, amongst other sources. In the body, acetaldehyde affects several tissues, particularly the brain and liver, causing various diseases, including cancer, alcoholic liver disease and Alzheimer’s. Acetaldehyde-Related Pathology describes the toxic effects of acetaldehyde at the tissue and cellular levels, reviewing enzyme biochemistry, transgenic mouse models of alcohol dehydrogenase mutants, and the cell-signalling pathways implicated in alcohol-related pathology. It explor...
It's a critical cliché that Cervantes' Don Quixote is the first modern novel, but this distinction raises two fundamental questions. First, how does one define a novel? And second, what is the relationship between this genre and understandings of modernity? In Forms of Modernity, Rachel Schmidt examines how seminal theorists and philosophers have wrestled with the status of Cervantes' masterpiece as an 'exemplary novel', in turn contributing to the emergence of key concepts within genre theory. Schmidt's discussion covers the views of well-known thinkers such as Friedrich Schlegel, José Ortega y Gasset, and Mikhail Bakhtin, but also the pivotal contributions of philosophers such as Hermann Cohen and Miguel de Unamuno. These theorists' examinations of Cervantes's fictional knight errant character point to an ever-shifting boundary between the real and the virtual. Drawing from both intellectual and literary history, Forms of Modernity richly explores the development of the categories and theories that we use today to analyze and understand novels.
Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
Is your firm’s board creating value—or destroying it? Change is coming. Leadership at the top is being redefined as boards take a more active role in decisions that once belonged solely to the CEO. But for all the advantages of increased board engagement, it can create debilitating questions of authority and dangerous meddling in day-to-day operations. Directors need a new road map—for when to lead, when to partner, and when to stay out of the way. Boardroom veterans Ram Charan, Dennis Carey, and Michael Useem advocate this new governance model—a sharp departure from what has been demanded by governance activists, raters, and regulators—and reveal the emerging practices that are de...
Gastroenterology and Hepatology encompass a vast anatomic assortment of organs with diverse structure and function and the potential for affliction from a multiplicity of diseases. Completely covering these complex and interrelated systems, Mayo Clinic Gastroenterology and Hepatology Board Review provides an in-depth examination of essential knowledge in gastroenterology, hepatology, and the integral related areas of pathology, endoscopy, nutrition, and radiology. With contributions from experts at Mayo Clinic who are currently in clinical practice and have a strong commitment to teaching, the book assists physicians-in-training to prepare for the gastroenterology board examination.
Each chapter presents a detailed background of the described method, its theoretical foundations, and its applicability to different biomedical material. Updated chapters describe either the most popular methods or those processes that have evolved the most since the past edition. Additionally, a large portion of the volume is devoted to clinical cytometry. Particular attention is paid to applications of cytometry in oncology, the most rapidly growing area. - Contains 56 extensive chapters authored by world authorities on cytometry - Covers a wide range of topics, including principles of cytometry and general methods, cell preparation, tandardization and quality assurance, cell proliferation...
Gets traders and investors up to speed on the hottest new approach to predicting the markets One of the most talked-about new forecasting tools in today's international markets, dynamic technical analysis (DTA) arms traders and investors with unprecedented insights into market volatility, price changes, and market trends. DTA is also a valuable money management tool and is much easier for money managers to master than traditional technical analysis techniques. The first practical introduction to this powerful new approach, Dynamic Technical Analysis provides readers with all the tools and know-how necessary to unlock the full power of DTA. * The only guide devoted exclusively to a powerful new forecasting technique * Uses numerous real-world trading examples to quickly acquaint readers with state-of-the art DTA principles and practices Phillippe Cahen (Paris, France) is Head of Technical Analysis for Credit Lyonnais Capital Markets in Paris.
Black Robe, an account of the 17th-century encounter between the Huron and Iroquois the French called "Les Sauvages" and the French Jesuit missionaries the native people called "Blackrobes," is Brian Moore's most striking book. No other novel has so well captured both the intense--and disastrous--strangeness of each culture to one another, and their equal strangeness to our own much later understanding.