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Causal Learning
Understanding causal structure is a central task of human cognition. Causal learning underpins the development of our concepts and categories, our intuitive theories, and our capacities for planning, imagination and inference. During the last few years, there has been an interdisciplinary revolution in our understanding of learning and reasoning: Researchers in philosophy, psychology, and computation have discovered new mechanisms for learning the causal structure of the world. This new work provides a rigorous, formal basis for theory theories of concepts and cognitive development, and moreover, the causal learning mechanisms it has uncovered go dramatically beyond the traditional mechanisms of both nativist theories, such as modularity theories, and empiricist ones, such as association or connectionism.
Decoding Cancer-relevant Splicing Networks in CD19 and MST1R
Alternative splicing is a highly complex cellular mechanism that enhances the protein-coding capacity of higher eukaryotic genomes. Like any complex process, it is prone to errors. These can lead to health-related issues. Nowadays, erroneous splicing is even considered one of the hallmarks of cancer. In this work, we investigated two different cancer-related splicing events. In MST1R proto-oncogene, skipping of exon 11 results in a pathological splicing isoform that leads to progression and metastasis in cancer. In CD19, aberrant splicing of exon 2 has been associated with failure of the CAR-T cell therapy targeting CD19 (CART-19). In both cases, we used a high-throughput minigene reporter a...
Alternative Splicing and Cancer
This book Alternative Splicing and Cancer explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer. Diving deep into the complexities of gene expression and protein diversity, the book illuminates how abnormal splicing contributes to aggressive tumor formation, affecting cellular functions such as proliferation, survival, and immune evasion. With a focus on understanding molecular mechanisms, this book unravels potential diagnostic and prognostic targets, opening doors for enhanced anti-cancer treatment efficacy. An indispensable resource for anyone intrigued by the interplay between gene splicing and cancer biology, it paves the way towards innovative therapeutic strategies.
Social Neuroscience
Social neuroscience uses the methodologies and tools developed to measure mental and brain function to study social cognition, emotion, and behavior. In this collection, John Cacioppo, Penny Visser, and Cynthia Pickett have brought together contributions from psychologists, neurobiologists, psychiatrists, radiologists, and neurologists that focus on the neurobiological underpinnings of social information processing, particularly the mechanisms underlying "people thinking about thinking people." In these studies, such methods as functional brain imaging, studies of brain lesion patients, comparative analyses, and developmental data are brought to bear on social thinking and feeling systems --...
Experiencing The Unconventional: Science In Art
This book introduces art projects that resulted from unconventional explorations, curious experiments and their creative translations into sensorial experiences. Using electronic and digital art, bioart, sculpture and installations, sound and performance, the authors are removing boundaries between natural and artificial, real and imaginary, science and culture.The invited artists and researchers come from cutting-edge fields of art production that focuses on creating aesthetic experiences and performative situations. Their artworks create a spatial aesthetic experience for visitors by manifesting themselves in physical space. Experiencing the Unconventional is a unique selection of works by artists not based on formal similarities, but on investigative practices. It offers in-depth insights and first-hand working experiences into current production of art works at the edge of art, science and technology.
The Oxford Handbook of the Self
The Oxford Handbook of the Self explores a fascinating diversity of questions about our understanding of self from a variety of interdisciplinary perspectives, including philosophy, ethics, psychology, neuroscience, psychopathology, narrative, and postmodern theories.
The Intellectual Lives of Children
A look inside the minds of young children shows how we can better nurture their abilities to think and grow. Adults easily recognize children’s imagination at work as they play. Yet most of us know little about what really goes on inside their heads as they encounter the problems and complexities of the world around them. In The Intellectual Lives of Children, Susan Engel brings together an extraordinary body of research to explain how toddlers, preschoolers, and elementary-aged children think. By understanding the science behind how children observe their world, explain new phenomena, and solve problems, parents and teachers will be better equipped to guide the next generation to become p...
Technology's Child
How children engage with technology at each stage of development, from toddler to twentysomething, and how they can best be supported. What happens to the little ones, the tweens, and the teenagers, when technology—ubiquitous in the world they inhabit—becomes a critical part of their lives? This timely book Technology's Child brings much-needed clarity to what we know about technology’s role in child development. Better yet, it provides guidance on how to use what we know to help children of all ages make the most of their digital experiences. From toddlers who are exploring their immediate environment to twentysomethings who are exploring their place in society, technology inevitably ...
Evolution and the Mechanisms of Decision Making
A multidisciplinary examination of cognitive mechanisms, shaped over evolutionary time through natural selection, that govern decision making. How do we make decisions? Conventional decision theory tells us only which behavioral choices we ought to make if we follow certain axioms. In real life, however, our choices are governed by cognitive mechanisms shaped over evolutionary time through the process of natural selection. Evolution has created strong biases in how and when we process information, and it is these evolved cognitive building blocks—from signal detection and memory to individual and social learning—that provide the foundation for our choices. An evolutionary perspective thu...
