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An Introduction to Molecular Medicine and Gene Therapy
  • Language: en
  • Pages: 408

An Introduction to Molecular Medicine and Gene Therapy

An Introduction to Molecular Medicine and Gene Therapy Edited by Thomas F. Kresina, Ph.D. Gene therapy, or the use of genetic manipulation for disease treatment, is derived from advances in genetics, molecular biology, clinical medicine, and human genomics. Molecular medicine, the application of molecular biological techniques to disease treatment and diagnosis, is derived from the development of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An Introduction to Molecular Medicine and Gene Therapy provides a basis for interpreting new clinical and basic research findings in the areas of cloning, gene transfer, and targeting; the applications of genetic medi...

The Fragile X Syndrome – Where Do We Go?
  • Language: en
  • Pages: 255

The Fragile X Syndrome – Where Do We Go?

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Dendritic spines: from shape to function
  • Language: en
  • Pages: 237

Dendritic spines: from shape to function

One fundamental requisite for a comprehensive view on brain function and cognition is the understanding of the neuronal network activity of the brain. Neurons are organized into complex networks, interconnected through synapses. The main sites for excitatory synapses in the brain are thin protrusions called dendritic spines that emerge from dendrites. Dendritic spines have a distinct morphology with a specific molecular organization. They are considered as subcellular compartments that constrain diffusion and influence signal processing by the neuron and, hence, spines are functional integrative units for which morphology and function are tightly coupled. The density of spines along the dend...

Modeling Fragile X Syndrome
  • Language: en
  • Pages: 384

Modeling Fragile X Syndrome

Introduction.-Probing Astrocyte Function in Fragile X Syndrome.- Neural Stem Cells.- Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System.– The Role of the Postsynaptic Density in the Pathology of the Fragile X Syndrome.- Behavior in a Drosophila model of Fragile X.- Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome.- Fragile X Mental Retardation Protein and Stem Cells.- Manipulating the Fragile X Mental Retardation Proteins in the Frog.- Exploring the Zebra finch Taeniopygia gutta as a Novel Animal Model for the Speech-language Deficit of Fragile X Syndrome.- Neuroendocrine Alterations in the Fragile X Mouse.- Taking STEPs forward to understanding Fragile X Syndrome.- Fmr-1 as an Offspring Genetic and a Maternal Environmental Factor in Neurodevelopmental Disease.- Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome.- Clinical Aspects of the Fragile X Syndrome.- Fragile X Syndrome: A Psychiatric Perspective.- Fragile X Syndrome and Targeted Treatment Trials.- The Fragile X-associate Tremor Ataxia Syndrome.- Vignettes: Models in Absentia.

The Journal of Neuroscience
  • Language: en
  • Pages: 778

The Journal of Neuroscience

  • Type: Book
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  • Published: 2002
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  • Publisher: Unknown

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Abstracts of the ... Annual Meeting of the European Neuroscience Association
  • Language: en
  • Pages: 1018
Chromaffin Cell Excitability and BK Channel Gating
  • Language: en
  • Pages: 390

Chromaffin Cell Excitability and BK Channel Gating

  • Type: Book
  • -
  • Published: 2008
  • -
  • Publisher: Unknown

None

Membership Directory
  • Language: en
  • Pages: 570

Membership Directory

  • Type: Book
  • -
  • Published: 1995
  • -
  • Publisher: Unknown

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Society for Neuroscience Abstracts
  • Language: en
  • Pages: 1446

Society for Neuroscience Abstracts

  • Type: Book
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  • Published: 1997
  • -
  • Publisher: Unknown

None

Selective Neuronal Death
  • Language: en
  • Pages: 292

Selective Neuronal Death

Parkinson's disease, Alzheimer's disease, and motor neuron disease share a significant common feature: selective death of neurons in restricted regions of the brain. This international symposium, held by the Ciba Foundation in 1986, is the first to bring together neurophysiologists working on neuronal death and neuropathologists dealing with human degenerative brain disease. Participants describe the causes and sequence of events leading to neuronal death and discuss what can be done to prevent it. Among the topics covered are recent advances in the understanding of agents such as trophic factors, excitotoxins and poisons that are known to be involved in neuronal death; examples of neuronal death during normal development; and the role played by endocrine mechanisms and neuronal activity. Also considers trophic factors controlling the survival of neuronal transplants and the therapeutic prospects for tissue transplantation.