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Principles of Tumors
Principles of Tumors covers all of the fundamental aspects of tumors, including their definitions, incidences, causation, pathogenesis, treatments, and prevention. The book provides a unique approach, integrating a wide range of basic bioscience findings with clinico-pathological observations and phenomena encountered in their treatment. As tumors are studied in fairly separate, broad areas, such as basic biological sciences, pathology, oncology, and epidemiology, this book brings together these perspectives, providing an all-inclusive text that benefits all researchers, while also providing an avenue for translational research. Integrates both cell mechanisms and tumor physiopathology Brings together research and perspectives from basic biological sciences, pathology, oncology, and epidemiology, providing an all-inclusive text Provides a concise tumor reference for the tumor researcher and oncologist Includes appendices for foundational material Brings out the cell detail of tumors
Principles of Tumors
Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the...
Cancer: Cell Structures, Carcinogens and Genomic Instability
This volume began with an invitation from the publishers to edit a volume of EXS on Cancer. This invitation undoubtedly derived from my articles in Cellular and Molecular Life Sciences in 2002 and 2003 on the relationships between the morphology, aetiology and pathogenesis of tumours, especially in relation to genetic instability. After many years of teaching the theories of c- cer in undergraduate medical school courses, it seemed to me that the variably chaotic histopathologic features of tumours parallel in some way, the variably unstable genomes of tumour cells, which were being discovered in the 1990s. Thus the title of the volume has come to include morphology, carcinogenesis and genet...
David Paul von Hansemann: Contributions to Oncology
In the late nineteenth century, David Paul von Hansemann coined phrases that have remained the basis of descriptive terms concerning the microscopical appearances of tumors ever since, yet his work is rarely mentioned today. This book presents translations of all the relevant German texts and analyses the background and context of Hansemann's theories. It shows that some of Hansemann’s ideas may still be relevant to cancer research today.
Virchow's Eulogies
Rudolph Virchow (1821-1902) was a leading figure in the medical, political and intellectual life of Germany in the second half of the nineteenth century. His most famous work was "Cellular Pathology". Virchow wrote many books and edited several journals, including ‘Virchow’s Archive’ and was a member of numerous professional societies. This book is a compilation of Virchow's memorial addresses on nineteen of his teachers –especially Johannes Müller and Johann Lukas Schönlein – colleagues and students as well as one concerning Morgagni. There is an introduction to the man and his times, and copious editors' notes to explain allusions and events mentioned in the text with which some modern readers may be unfamiliar. There is also an extensive bibliography incorporating German sources, with English translations of all titles. The book gives a fascinating multi-dimensional view of scientists and their lives in nineteenth century Germany.
Cancer: Cell Structures, Carcinogens and Genomic Instability
Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related. The volume will be of interest to all those who are involved in cancer research or in the prevention, diagnosis or management of tumors in humans or animals.
New Research on Genomic Instability
Many cancer biologists now believe that genomic instability not only initiates carcinogenesis, but also allows the tumour cell to become metastatic and evade drug toxicity. The loss of stability of the genome is becoming accepted as one of the most important aspects of carcinogenesis. One of the hallmarks of the cancer cell is the inherent instability of its genome. This book presents important research in this exciting field.
The Truth in Small Doses
A decade ago Leaf, a cancer survivor himself, began to investigate why we had made such limited progress fighting this terrifying disease. The result is a gripping narrative that reveals why the public's immense investment in research has been badly misspent, why scientists seldom collaborate and share their data, why new drugs are so expensive yet routinely fail, and why our best hope for progress-- brilliant young scientists-- are now abandoning the search for a cure.
International Review of Cytology
International Review of Cytology
Fractals in Biology and Medicine
This volume is number four in a series of proceedings volumes from the International Symposia on Fractals in Biology and Medicine in Ascona, Switzerland which have been inspired by the work of Benoît Mandelbrot seeking to extend the concepts towards the life sciences. It highlights the potential that fractal geometry offers for elucidating and explaining the complex make-up of cells, tissues and biological organisms either in normal or in pathological conditions.
