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Human Glucose Transporters in Health and Diseases
Glucose transporters play an important role in the metabolism of both humans and animals. These membrane proteins mediate the transport of several substances, such as monosaccharides, inositols, vitamins, and iodide, across the plasma membrane. Disturbances in expression and function of these carrier proteins usually cause severe or even fatal outcomes. This book discusses a series of current issues regarding the correlations between the expression of these transporters and diseases, including the role of glucose transporters as a potential anticancer and antidiabetic therapeutic target. By presenting a clear review of the correlation between glucose transporter-health and disease, the book will serve to draw more biomedical scientists, physicians, pharmacologists, physiologists, and students to dedicate their research to the role of glucose transporters in human health and disease.
Blood Glucose Levels
The main source of energy for the body is glucose. Its low blood concentrations can cause seizures, loss of consciousness and death. Long lasting high glucose levels can cause blindness, renal failure, cardiac and peripheral vascular disease, and neuropathy. Blood glucose concentrations need to be maintained within narrow limits. The process of maintaining blood glucose at a steady state is called glucose homeostasis. This is achieved through a balance of the rate of consumption of dietary carbohydrates, utilization of glucose by peripheral tissues, and the loss of glucose through the kidney tubule. The liver and kidney also play a role in glucose homeostasis. This book aims to provide an overview of blood glucose levels in health and diseases.
Adipose Tissue
Adipose tissue, a kind of connective tissue, plays different and significant roles in the human body. Its function includes protection against environmental factors, storage of lipids and triacylglycerol, and the process of thermogenesis. It is also involved in the secretion of highly active biomolecules such as steroid hormones, prostaglandins, as well as proteins called “adipokines.” On the other hand, disturbances in functions of adipose tissue may cause several pathologies such as obesity and insulin resistance. Obesity is a worldwide health problem, whereas diabetes mellitus due to insulin resistance is defined by the World Health Organization as “a progressive worldwide epidemic.” Especially dangerous is visceral accumulation of adipose tissue.This book describes a series of up-to-date topics about physiological and pathological processes in adipose tissue.
Glucose Homeostasis and Insulin Resistance
"Glucose homeostasis and insulin resistance presents a broad overview of the molecular, biochemical and clinical aspects of glucose metabolism and glucose resistance. The book serves to acquaint the reader with recent information on topics ranging from the"
Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s Disease
Despite being confined to the gastrointestinal tract, the gut microbiome has a wide impact on human physiology, supplementing its host’s biochemistry in a complex symbiotic relationship. Research in the field has evolved rapidly in the last decade, and we are now developing a better understanding of how our gut microbiome can influence our immune systems, metabolism, neurological signaling, and perhaps most unexpectedly, our brains; a phenomenon described as the gut-brain-axis. This book, ‘Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s Disease’, sets out to explore the complex role of the microbiome with regard to Alzheimer’s disease (AD). The microbiome is a critical and...
Glucose Homeostasis
Most tissues and organs, such as the brain, need glucose constantly, as an important source of energy. The low blood concentrations of glucose (hypoglycemia) can cause seizures, loss of consciousness, and death. On the other hand, long lasting elevation of blood glucose concentrations (hyperglycemia) can result in blindness, renal failure, cardiac and peripheral vascular disease, and neuropathy. Therefore, blood glucose concentrations need to be maintained within narrow limits. The process of maintaining blood glucose at a steady-state level is called glucose homeostasis. This is accomplished by the finely hormone regulation of peripheral glucose uptake (glucose utilization), hepatic glucose production and glucose uptake during carbohydrates ingestion.
Gluconeogenesis
Gluconeogenesis, the metabolic process through which glucose or glycogen is synthesized from noncarbohydrate substrates, is critical for maintaining the plasma glucose level within a narrow range either in the fed or fasting (nutritional deprivation) state. Dysregulation of this pathway usually causes severe or even fatal outcomes. This book discusses a series of up-to-date topics about this critical process, including the fundamental biochemical reactions of glucose metabolism, the glucogenesis process in eukaryotic cells using the Dictyostelium discoideum as a model, the role of "gut-brain-liver axis" in the control of glucose homeostasis, and the new mathematic model for the monitoring and prediction of blood glucose. This book is written by international scientists with expertise in the study of gluconeogenesis. By presenting a clear and succinct review of the fundamentals of gluconeogenesis, it is expected to draw more attentions and stimulate more scientists to dedicate their researches in revealing the mechanism and its application of gluconeogenesis.
Diabetes
Over the last few decades the prevalence of diabetes has dramatically grown in most regions of the world. In 2010, 285 million people were diagnosed with diabetes and it is estimated that the number will increase to 438 million in 2030. Hypoglycemia is a disorder where the glucose serum concentration is usually low. The organism usually keeps the serum glucose concentration in a range of 70 to 110 mL/dL of blood. In hypoglycemia the glucose concentration normally remains lower than 50 mL/dL of blood. Hopefully, this book will be of help to many scientists, doctors, pharmacists, chemicals, and other experts in a variety of disciplines, both academic and industrial. In addition to supporting researcher and development, this book should be suitable for teaching.
Adipose Tissue
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Glucose Homeostasis
Glucose is the main and preferred source of energy for mammalian cells. Mammalian cells need glucose constantly. Long-lasting disturbances in blood glucose concentrations can cause diseases and death. Therefore, blood glucose concentrations must be within narrow limits. The process of maintaining blood glucose at a steady-state level is called glucose homeostasis.
