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Advances of Novel Approaches to Enhance Therapeutic Efficacy and Safety in Human Solid Cold Tumor
Immune checkpoint inhibitors (ICI), such as anti-CTLA-4 and anti-PD-1/PD-L, have demonstrated significant clinical effects on the neutralization of immunosuppressive mechanisms in the tumor microenvironment (TME). Over the years, tremendous advances have been made in cancer immunotherapy, yet we are far from discovering the cure for the disease.
Regulating Gut Microbiota by Lactic Acid Bacteria: Effects Based on Probiotic Characteristics and Their Metabolites
Lactic acid bacteria are a type of important probiotic that may be found in a wide range of nutrient-rich habitats, including food, feed, soil, and organisms like animals as well as plants. According to the U.S. Food and Drug Administration, many species of lactic acid bacteria and their metabolites are “generally regarded as safe (GRAS)”. The most commonly used strains as probiotics spread in genera Lactobacilli, Bifidobacterium, Lactococcus, Enterococcus, and Streptococcus. They have been shown to enhance intestinal transit, balance gut microbiota, and preserve the colon's acid-base equilibrium, which regulates the immune system and lowers serum cholesterol levels.
Combinational Immunotherapy of Cancer: Novel Targets, Mechanisms, and Strategies
Cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has revolutionized the paradigm in cancer treatment. However, the clinical outcome of immunotherapy varies considerably among patients and only a minority of patients achieve long-term clinical benefits. This is largely attributed to the fact that existing cancer immunotherapies, which concentrate on several classical targets (CTAL-4, PD-1/PD-L1, etc.) and limited types of immune cell populations (T cells), are insufficient to cope with the complexity of highly heterogeneous tumor microenvironment (TME). This calls for more efforts to not only expand our toolbox for manip...
The Peony Pavilion
A celebrated translation of this masterpiece of Chinese literature, in an updated edition
Network Pharmacology and Traditional Medicine
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Frontier Computing
This book gathers the proceedings of the 9th International Conference on Frontier Computing, held in Kyushu, Japan on July 9–12, 2019, and provides comprehensive coverage of the latest advances and trends in information technology, science and engineering. It addresses a number of broad themes, including communication networks, business intelligence and knowledge management, web intelligence, and related fields that inspire the development of information technology. The respective contributions cover a wide range of topics: database and data mining, networking and communications, web and internet of things, embedded systems, soft computing, social network analysis, security and privacy, optical communication, and ubiquitous/pervasive computing. Many of the papers outline promising future research directions, and the book will benefit students, researchers and professionals alike. Further, it offers a useful reference guide for newcomers to the field.
Reborn To Be A Vicious Phoenix
In the first year of Zhenyuan, Dingkang County, Hean Prefecture, a woman transformed into a monster. Luo Qingcai had spent nine years helping her husband. The Heavens did not disappoint those who had worked hard for her. As soon as he ascended the clouds, he kicked her into the abyss where she would never be able to recover! "He said you were as stupid as a pig or a dog and not worthy to be the supervisor lady." The eldest young mistress smiled sweetly as she looked at the corpse nailed to the coffin. "You little bastard, you're still quite useful. At least you raised me a husband for the top scholar." Once they were reborn, she was going to make them suffer through all the suffering in this world!
