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Therapeutic Implications of Circadian Rhythms
Circadian rhythms are biological processes displaying endogenous and entrainable oscillations of about 24 hours. They are driven by a group of genes called clock genes that have been widely observed in plants, animals and even in bacteria. In mammals, the core clock genes are rhythmically expressed in both the suprachiasmatic nucleus (SCN), the master clock residing in the hypothalamus, and almost all peripheral tissues where they control numerous target genes in a circadian manner, and thus affect many physiological and biochemical processes. Evidence suggests that disruption of the circadian rhythms (or desynchronization) is a significant risk factor for the development of metabolic diseas...
Aging People, Aging Places
Bringing together academic research, practitioner reflections and personal narratives from older adults across Canada, this text provides a rare spotlight on the local implications of aging in Canadian cities and communities. They provide a wide-ranging and comprehensive discussion of how to build supportive communities for Canadians of all ages.
