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Metal economy in host-microbe interactions
This Research Topic presents knowledge on transition metal metabolism in various infections from the dual perspective of offender and defender. 1) Host Nutritional Immunity: depriving or poisoning. To date, the implication of divalent metals have been described in two different immune strategies that aim to fight microbial invaders. One consists in depriving microbes of essential divalent metals whereas the other aims at overloading invaders with toxic concentrations of metal. The contributions in this section present, in different situations, various aspects of this metal economy at the host-microbe interface. Two papers deal with metal homeostasis as hosts interact with bacteria. Diaz-Ocho...
Fungal Physiology and Immunopathogenesis
This volume offers an overview of the various aspects involved in the ability of fungi to damage host cells, and discusses cutting-edge approaches to the study of fungal pathogenesis. The first chapter illustrate the key roles of glycans and pigments, the most abundant surface components in fungal cells, in their interactions with host cells. The connections between cellular physiology and fungal pathogenesis are then discussed in the following chapters. Physiology-related processes affecting pathogenesis include fungal secretion, morphological transitions, and response to light. In turn, the book illustrates mechanisms of damage to host cells using the Histoplasma capsulatum model of infect...
Scholars in COVID Times
Scholars in COVID Times documents the new and innovative forms of scholarship, community collaboration, and teaching brought about by the COVID-19 pandemic. In this volume, Melissa Castillo Planas and Debra A. Castillo bring together a diverse range of texts, from research-based studies to self-reflective essays, to reexamine what it means to be a publicly engaged scholar in the era of COVID. Between social distancing, masking, and remote teaching—along with the devastating physical and emotional tolls on individuals and families—the disruption of COVID-19 in academia has given motivated scholars an opportunity (or necessitated them) to reconsider how they interact with and inspire stude...
Sozialer Zusammenhalt in der Krise
Krisen verschärfen gesellschaftliche Problemlagen bzw. lassen diese besonders deutlich hervortreten. Zugleich werfen krisenbedingte Einschnitte in bisher selbstverständliche Gewohnheiten grundlegende Fragen zum Zusammenleben in modernen Staaten und zur Funktionsweise gesellschaftlicher Institutionen auf. Vor dem Hintergrund der Corona-Pandemie leuchten die Beiträger*innen des Bandes das Thema der gesellschaftlichen Kohäsion in Krisenzeiten aus unterschiedlichen Fachrichtungen näher aus. Sie diskutieren nicht nur grundlegende sozialtheoretische Fragen und empirische Forschungsergebnisse zum Thema, sondern analysieren auch Handlungsansätze der Solidarisierung in Zeiten der Krise.
The Fungal Cell Wall
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Fungal Pathogenesis in Humans
Dear Colleagues, Cancer survival rates and successful organ transplantation in patients continues to increase due to improvements in early diagnosis and treatments. Since immuno-suppressive therapies are frequently used, the mortality rate due to secondary infections has become an ever-increasing problem. Opportunistic fungal infections are probably the deadliest threat to these patients due to their difficult early diagnosis, the limited effect of antifungal drugs and the appearance of resistances. In recent years, a considerable effort has been devoted to investigating the role of many virulence traits in the pathogenic outcome of fungal infections. New virulence factors (hypoxia adaptatio...
Pandemic Pedagogies
Pandemic Pedagogies: Teaching and Learning during the COVID-19 Pandemic provides critical insights into the impact of the pandemic on the education system, pedagogical approaches, and educational inequalities. Education is often touted as the best way to promote social mobility and produce informed members of society. The pandemic has significantly threatened those goals by temporarily disrupting education and exacerbating disparities in the education system. The scholarship in this volume takes a closer look at many of the issues at the heart of the educational process including teacher self-efficacy, the gendered and racialized impacts of the pandemic on education, school closures, and institutional responses. Drawing on the expertise of scholars from around the world, the work presented here represents a remarkable diversity and quality of impassioned scholarship on the impact of COVID-19 and is a timely and critical advance in knowledge related to the pandemic.
Vaccines, Immunotherapy and New Antifungal Therapy Against Fungi: Updates in the New Frontier
Invasive fungal diseases have increased many fold over the past 50 years. Current treatment regimens typically require prolonged administration of antifungal medications that can have significant toxicity. Moreover, our present potent antifungal armamentarium fails to eradicate fungal pathogens from certain compromised hosts. Additionally, invasive fungal diseases continue to have unacceptably high mortality rates. A growing body of work has focused on the utility of vaccines and/or immunotherapy as a powerful tool in combating mycoses, either for the active treatment, as an adjuvant, or in the prevention of specific fungal pathogens. Also, it is growing the interest over new drugs development as second choice for treatment when traditional chemotherapy fail. This Research Topic will detail the exciting progress in developing vaccines, immunotherapy and new drugs for fungi.
