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This volume discusses different aspects of immune homeostasis regulation and its dysregulation during various diseases, including infections, cancers, neurodegenerative diseases, autoinflammation, autoimmune diseases, and immunodeficiency, along with immunological, genetic, cell biology, and molecular biology techniques designed to understand immune homeostasis at different stages. The chapters in this book cover topics such as T cell subsets; monocyte-myofibroblast immunomodulation in a 3D co-culture system; human peripheral blood mononuclear cells in patients with neurodegenerative diseases; and CRISPR-Cas9 induced gene-editing in primary human monocytes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Immune Homeostasis: Methods and Protocols is a valuable resource for both novice and experts researchers interested in learning more about this important and developing field.
Engineering Technology and Applications contains the contributions presented at the 2014 International Conference on Engineering Technology and Applications (ICETA 2014, Tsingtao, China, 29-30 April 2014). The book is divided into three main topics: – Civil and environmental engineering – Electrical and computer engineering – Mechanical engineering Considerable attention is also paid to big data, cloud computing, neural network algorithms and social network services. The book will be invaluable to professionals and academics in civil, environmental, electrical, computer and mechanical engineering.
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In the post genomic era, understanding of the innate immune system is enriched by findings on the specificity of innate immune reactions as well as to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. This volume covers natural killer cells, mast cells, phagocytes, toll-like receptors, complement, host defense in plants and invertebrates, evasion strategies of microorganisms, pathophysiology, protein structures, design of therapeutics, and experimental approaches.
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This is the first book to explain the integration of object technology and knowledge software development. Daniel Rasmus has surveyed his own body of work and gathered and reworked the most important and relevant material from his contributions to Object Magazine, in order to explain how to create intelligent software to control and automate the functional units of information created through object technology.
This book constitutes the refereed proceedings of the 9th Pacific Rim International Conference on Artificial Intelligence, PRICAI 2006, held in Guilin, China in August 2006. The book presents 81 revised full papers and 87 revised short papers together with 3 keynote talks. The papers are organized in topical sections on intelligent agents, automated reasoning, machine learning and data mining, natural language processing and speech recognition, computer vision, perception and animation, and more.