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The definitive biography of the legendary Empresario who colonized Texas for the Mexican government before leading the Texas Revolution. First published in 1925, The Life of Stephen F. Austin remains one of the finest works of Texas biography. An historian at the University of Texas, Eugene C. Barker spent nearly twenty-five years researching and writing this magisterial narrative, combining impeccable academic standards with engaging and lively prose. The son of Moses Austin, who received an empresario grant from Spain to settle Texas, Stephen took the mantle and began settling the region for the newly independent state of Mexico. He sold parcels of land to families of Anglo-Americans who later became known as the Old Three Hundred. When this growing Anglo community rebelled against the Mexican government, Austin led volunteer forces to victory at the Siege of Bexar and later served as Secretary of State for the Republic of Texas under President Houston.
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Conceptual and technological advances in chemistry and biology have transformed the drug discovery process. Evolutionary pressure among the diverse scientific and engineering disciplines that contribute to the identification of biologically active compounds has resulted in synergistic improvements at every step in the process. Exploiting Chemical Diversity for Drug Discovery encompasses the many components of this transformation and presents the current state-of-the-art of this critical endeavour. From the theoretical and operational considerations in generating a collection of compounds to screen, to the design and implementation of high-capacity and high-quality assays that provide the mos...
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