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Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success. The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins.
It is estimated that in prehistoric societies children comprised at least forty to sixty-five percent of the population, yet by default, our ancestral landscapes are peopled by adults who hunt, gather, fish, knap tools and make art. But these adults were also parents, grandparents, aunts and uncles (however they would have codified these kin relationships) who had to make space physically, emotionally, intellectually, and cognitively for the infants, children and adolescents around them. The economic, social, and political roles of Paleolithic children are often understudied because they are assumed to be unknowable or negligible. Drawing on the most recent data from the cognitive sciences a...
This volume brings together the advanced research results obtained by the European COST Action 2102 "Cross Modal Analysis of Verbal and Nonverbal Communication", primarily discussed at the PINK SSPnet-COST2102 International Conference on Analysis of Verbal and Nonverbal Communication and Enactment: The Processing Issues, held in Budapest, Hungary, in September 2010. The 40 papers presented were carefully reviewed and selected for inclusion in the book. The volume is arranged into two scientific sections. The first section, Multimodal Signals: Analysis, Processing and Computational Issues, deals with conjectural and processing issues of defining models, algorithms, and heuristic strategies for data analysis, coordination of the data flow and optimal encoding of multi-channel verbal and nonverbal features. The second section, Verbal and Nonverbal Social Signals, presents original studies that provide theoretical and practical solutions to the modelling of timing synchronization between linguistic and paralinguistic expressions, actions, body movements, activities in human interaction and on their assistance for an effective human-machine interactions.
The Fifteen American Peptide Symposium (15APS) was held in Nashville, Tennessee, on June 14-19, 1997. This biennial meeting was jointly sponsored by the American Peptide Society and Vanderbilt University. The attendance of 1,081 participants from 37 countries was lower than the two previously held Symposia. However, the number of participating countries was the largest. Thus, it was gratifying to see that this meeting retained both its international flavor and participant loyalty at a time when there are many more symposia held each year on similar subjects. The scientific program, thanks to the insights and efforts of the Program Committee as well as Dr. Peter Schiller, the President of the...
Loïc sent que son cerveau est sur le point d’exploser. Derrière lui, il entend des pas qui s’approchent. Les deux ravisseurs rejoignent la cuisine... Loïc, 14 ans, part en voyage avec sa famille, à bord du vieux Westfalia que Papi leur a légué. Alors que l’été s’annonçait des plus ennuyants, l’adolescent découvre qu’un portail temporel se cache dans le véhicule. La chasse au trésor préparée par son grand-père prend à ce moment une tournure étonnante. Si la famille envisage maintenant de mettre le cap vers les Maritimes, Loïc doit d’abord réussir à se sauver de la maison où il est retenu prisonnier... en 1970, et trouver un moyen de revenir dans le présent.
Trapped charge dating is a commonly used chronological tool in Earth Sciences and Archaeology. The two principle methods are luminescence dating and electron spin resonance. Both are based on stored energy produced by the absorption of natural radioactivity in common minerals such as quartz and feldspars, and in some biological materials such as tooth enamel. Methodological developments in the last 20 years have substantially increased the accuracy and precision of these methods. This compilation offers a taste of the recent research into both method and applications.
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High-throughput sequencing and functional genomics technologies have given us the human genome sequence as well as those of other experimentally, medically, and agriculturally important species, thus enabling large-scale genotyping and gene expression profiling of human populations. Databases containing large numbers of sequences, polymorphisms, structures, metabolic pathways, and gene expression profiles of normal and diseased tissues are rapidly being generated for human and model organisms. Bioinformatics is therefore gaining importance in the annotation of genomic sequences; the understanding of the interplay among and between genes and proteins; the analysis of the genetic variability of species; the identification of pharmacological targets; and the inference of evolutionary origins, mechanisms, and relationships. This proceedings volume contains an up-to-date exchange of knowledge, ideas, and solutions to conceptual and practical issues of bioinformatics by researchers, professionals, and industry practitioners at the 6th Asia-Pacific Bioinformatics Conference held in Kyoto, Japan, in January 2008.