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Morphogens in the Wiring of the Nervous System
Neuronal function relies on the establishment of proper connections between neurons and their target cells during development. This basic statement involves several cellular processes, such as neuronal differentiation, the polarized outgrowth of axons and dendrites from differentiated neurons, and the pathfinding of axons towards target cells. The subsequent recognition of complementary synaptic partners finally triggers the formation, maturation, and maintenance of functional synapses. Morphogens are secreted signaling molecules that regulate tissue patterning and cell identity during early embryonic development. Remarkably, growing evidence over the last years arising from different invertebrate and vertebrate model organisms has shown that, after cell fate has been established, morphogens also control the precise wiring of the nervous system.
Trends in Cell Signaling Pathways in Neuronal Fate Decision
During the last decades, numerous studies about stem cells and regenerative medicine highlighted new therapeutic approaches to treat several neurological disorders. It is noteworthy that the current optimism over potential stem cell therapies is driven by new understandings of stem cell biology leading to specific cell fate decision. The objectives of this book were: 1) to offer a general understanding of signaling pathways underlying the capacity of differentiation of several types of stem cells into neurons, during the development; 2) to understand how those pathways are altered in pathological conditions; 3) to describe advances in cellular therapy that could be use to restore central nervous system dysfunction in pathological conditions.
Protein Misfolding Disorders
Neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Prion-related disorders (PrD) and Huntington’s disease (HD) share a common neuropathology, primarily featuring the presence of abnormal protein inclusions containing specific misfolded proteins. These groups of diseases are now classified as Protein Misfolding Disorders. This book gives a comprehensive overview of the possible mechanisms involved in Protein Misfolding Disorders and possible therapeutic strategies to treat these diseases. The Ebook provides the most recent evidence addressing the role of cellular stress responses to neurological diseases, along with therapeutic strategies to alleviate ER stress in a disease context. -- Publisher.
The Routledge Handbook of Gender Archaeology
This volume presents a comprehensive overview of gender archaeology, both theory and practice, and contributes a substantial and definitive reference work by bringing together state-of-the-art research, theoretical overviews, and the latest debates in the field. Responding to the shifts in the theoretical landscape and the societal and political frameworks within which we produce our knowledge, chapters create both a solid theoretical baseline which help readers grasp the significance of gender in archaeology as well as offer perspectives on how to engender produced knowledge about the past. In line with recent focus on the shortcomings of gender and archaeological representation, chapters a...
Updates on Clostridioides difficile in Europe
This fully updated second edition outlines the currently available clinical, epidemiological and experimental data on Clostridioides difficile infections(CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution ...
Updates on Clostridium difficile in Europe
This book outlines the currently available clinical, epidemiological and experimental data on Clostridium difficile infection (CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is...
The Challenge of Economic Development
This book provides a general overview of the challenges of economic development for the five billion people living in developing countries. While they constitute over 80 percent of the world's population, they account for only 40% of the world's output, and are home to 2.6 billion people living on less than $2.00 per day. Thinking on economic development has shifted over time. Early theories that stressed capital formation and a heavy reliance on the public sector proved inadequate. Gradually, economists began to see that development was a complex, multifaceted problem that combined economic issues with problems of poverty and income distribution, insititution building and governance. While there have been many failures, there have also been many successes. Countries such as China, Chile, Ghana, and Korea demonstrate that good policies and strong institutions can result in remarkable progress. However, many poor countries, particularly those in Africa continue to lag behind. Closing this gap remains a major challenge for the world, particularly as the growing population and output of developing countries accelerate tensions in such areas as trade, immigration and financial flows.
Imputação Objectiva de Negócios de Risco à Acção de Infidelidade (Art. 224o, no 1 do Código Penal) - O Direito Penal no Mar Revolto da Crise Económico-Financeira
A crise económico-financeira do passado recente, além das graves consequências que provocou nos planos financeiro, económico e social, teve um forte impacto nos vários ramos do Direito, o Direito Penal incluído. O presente estudo é demonstração disso mesmo. Nele se pretende analisar até que ponto certos negócios de risco celebrados pelo top managment do sector financeiro, com prejuízos patrimoniais para as respectivas sociedades, correspondem à violação de deveres de lealdade integrantes do ilícito típico de infidelidade (art. 224o, no 1 do Código Penal). As conclusões não são tão intuitivas quanto à primeira vista parecem.
