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Protein Misfolding Disorders
Neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Prion-related disorders (PrD) and Huntington’s disease (HD) share a common neuropathology, primarily featuring the presence of abnormal protein inclusions containing specific misfolded proteins. These groups of diseases are now classified as Protein Misfolding Disorders. This book gives a comprehensive overview of the possible mechanisms involved in Protein Misfolding Disorders and possible therapeutic strategies to treat these diseases. The Ebook provides the most recent evidence addressing the role of cellular stress responses to neurological diseases, along with therapeutic strategies to alleviate ER stress in a disease context. -- Publisher.
Morphogens in the Wiring of the Nervous System
Neuronal function relies on the establishment of proper connections between neurons and their target cells during development. This basic statement involves several cellular processes, such as neuronal differentiation, the polarized outgrowth of axons and dendrites from differentiated neurons, and the pathfinding of axons towards target cells. The subsequent recognition of complementary synaptic partners finally triggers the formation, maturation, and maintenance of functional synapses. Morphogens are secreted signaling molecules that regulate tissue patterning and cell identity during early embryonic development. Remarkably, growing evidence over the last years arising from different invertebrate and vertebrate model organisms has shown that, after cell fate has been established, morphogens also control the precise wiring of the nervous system.
Trends in Cell Signaling Pathways in Neuronal Fate Decision
During the last decades, numerous studies about stem cells and regenerative medicine highlighted new therapeutic approaches to treat several neurological disorders. It is noteworthy that the current optimism over potential stem cell therapies is driven by new understandings of stem cell biology leading to specific cell fate decision. The objectives of this book were: 1) to offer a general understanding of signaling pathways underlying the capacity of differentiation of several types of stem cells into neurons, during the development; 2) to understand how those pathways are altered in pathological conditions; 3) to describe advances in cellular therapy that could be use to restore central nervous system dysfunction in pathological conditions.
The Routledge Handbook of Gender Archaeology
This volume presents a comprehensive overview of gender archaeology, both theory and practice, and contributes a substantial and definitive reference work by bringing together state-of-the-art research, theoretical overviews, and the latest debates in the field. Responding to the shifts in the theoretical landscape and the societal and political frameworks within which we produce our knowledge, chapters create both a solid theoretical baseline which help readers grasp the significance of gender in archaeology as well as offer perspectives on how to engender produced knowledge about the past. In line with recent focus on the shortcomings of gender and archaeological representation, chapters a...
Updates on Clostridioides difficile in Europe
This fully updated second edition outlines the currently available clinical, epidemiological and experimental data on Clostridioides difficile infections(CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution ...
Insights into Microbe-Microbe Interactions in Human Microbial Ecosystems: Strategies to be Competitive
All parts of our body having communication with the external environment such as the skin, vagina, the respiratory tract or the gastrointestinal tract are colonized by a specific microbial community. The colon is by far the most densely populated organ in the human body. The pool of microbes inhabiting our body is known as “microbiota” and their collective genomes as “microbiome”. These microbial ecosystems regulate important functions of the host, and their functionality and the balance among the diverse microbial populations is essential for the maintenance of a “healthy status”. The impressive development in recent years of next generation sequencing (NGS) methods have made po...
Updates on Clostridium difficile in Europe
This book outlines the currently available clinical, epidemiological and experimental data on Clostridium difficile infection (CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is...
Imputação Objectiva de Negócios de Risco à Acção de Infidelidade (Art. 224o, no 1 do Código Penal) - O Direito Penal no Mar Revolto da Crise Económico-Financeira
A crise económico-financeira do passado recente, além das graves consequências que provocou nos planos financeiro, económico e social, teve um forte impacto nos vários ramos do Direito, o Direito Penal incluído. O presente estudo é demonstração disso mesmo. Nele se pretende analisar até que ponto certos negócios de risco celebrados pelo top managment do sector financeiro, com prejuízos patrimoniais para as respectivas sociedades, correspondem à violação de deveres de lealdade integrantes do ilícito típico de infidelidade (art. 224o, no 1 do Código Penal). As conclusões não são tão intuitivas quanto à primeira vista parecem.
