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For long, high dose ionizing radiation was considered as a net immune suppressing agent, as shown, among others, by the exquisite radiosensitivity of the lymphoid system to radiation-induced cell killing. However, recent advances in radiobiology and immunology have made this picture more complex. For example, the recognition that radiation-induced bystander effects, share common mediators with various immunological signalling processes, suggests that they are at least partly immune mediated. Another milestone was the finding, in the field of onco-immunology, that local tumor irradiation can modulate the immunogenicity of tumor cells and the anti-tumor immune responsiveness both locally, in t...
This book explores the current difficulties and unsolved problems in the field of particle therapy and, after analysing them, discusses how (and if) innovative Monte Carlo approaches can be used to solve them. Each book chapter is dedicated to a different sub-discipline, including multi-ion treatments, flash-radiotherapy, laser-accelerated beams, nanoparticles effects, binary reactions to enhance radiobiology, and space-related issues. This is the first book able to provide a comprehensive insight into this exciting field and the growing use of Monte Carlo in medical physics. It will be of interest to graduate students in medicine and medical physics, in addition to researchers and clinical ...
High-energy charged particles represent a cutting-edge technique in radiation oncology. Protons and carbon ions are used in several centers all over the world for the treatment of different solid tumors. Typical indications are ocular malignancies, tumors of the base of the skull, hepatocellular carcinomas and various sarcomas. The physical characteristics of the charged particles (Bragg peak) allow sparing of much more normal tissues than it is possible using conventional X-rays, and for this reason all pediatric tumors are considered eligible for protontherapy. Ions heavier than protons also display special radiobiological characteristics, which make them effective against radioresistant a...
Questo libro consente al grande pubblico la fruizione di preziose fonti storiche sulla Calabria settecentesca. Si tratta di un mezzo di corredo archivistico, utile al reperimento del materiale e alla sua comprensione, grazie alle numerose citazioni, tratte dagli atti notarili, e a un corposo indice dei nomi, composto da oltre milleduecento voci. I documenti riguardano persone, proprietà e attività legate ad Amendolea, Bagaladi, Bova, Cardeto, Condofuri, Gallicianò, Melito, Montebello, Motta San Giovanni, Palizzi, Pentidattilo, Reggio, Roccaforte, Roghudi, San Lorenzo e Sant'Agata, ma anche a centri esterni all'area grecanica come Bagnara, Scilla e altri luoghi della Calabria Ulteriore.
Beginning with 1981, merger decisions of the Corporation are published separately as vol. 2 of the Annual report.