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MSC Communication in Physiological and Pathological Settings
Dr. Bourin works in a biotechnology company that develops a production process of ASC for clinical uses. Dr. Gimble is a co-founder, co-owner, and Chief Scientific Officer at Obatala Sciences and LaCell, biotechnology companies focused on the clinical translation of adipose-derived cells and tissues. The other Guest Editors declare no competing interests with regard to the Research Topic subject.
Molecular Regulation and Therapeutic Potential of Thermogenic Fat Cells
Obesity has emerged as a major threat to public health in both the western and developing world. Essentially a disorder of energy balance, obesity occurs when energy intake and storage exceeds expenditure. Much of energy homeostasis depends on the activity and function of adipose tissue. Adipocytes in mammals fall into two categories classified by their primary functions: white fat cells that mediate energy storage and thermogenic fat cells that counteract hypothermia and obesity through adaptive thermogenesis. Whereas white fat and its function as an energy reservoir and endocrine organ have been studied for decades and are relatively well understood, until recently many aspects of the ther...
Physiology and Physiopathology of Adipose Tissue
The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystoph...
Regenerative Medicine and Cell Therapy
Most human tissues do not regenerate spontaneously. Cell therapy and tissue engineering, which involve collecting cells from either the patient or a donor and introducing them into injured tissues or organs, sometimes after modifying their properties, offer promising solutions for regenerative medicine. Indeed, so promising are these therapies that current research has shifted from organ growth to cell therapy. The range of therapeutic applications is wide, including cardiac insufficiency, atherosclerosis, cartilage defects, bone repair, burns, diabetes and liver or bladder regeneration.This book, whilst not covering all aspects
Adipose Tissue and Adipokines in Health and Disease
This book presents a comprehensive survey of adipose tissue, its physiological functions, and its role in disease. The volume spans the entire range of adipose tissue studies, from basic anatomical and physiological research to epidemiology and clinical studies. Groundbreaking recent studies are incorporated into traditional models of adipose tissue properties. A description of the role of macrophages in obesity and metabolism in included.
The Reparable and the Irreparable
Since the mid-twentieth century, Western societies have seen an unprecedented increase in movements, demands, and policies in favor of reparations. The historical catastrophes that shook the last century are both the immediate origin of this groundswell and its founding paradigm. The Reparable and the Irreparable: Being Human in the Age of Vulnerability places reparation within a wider contemporary context and describes it in its full anthropological depth. Repair is a global phenomenon that does not present itself in a unified way. Ideas of repair and reparation are expressed at different levels; for instance, one can mend a damaged object, heal a wound, redress an injury, or make amends fo...
Stem Cells and Their Potential for Clinical Application
The NATO-ASI conference Stem Cells and Their Potential for Clinical Application featured cutting-edge presentations ranging from laboratory research findings to the latest therapeutic applications. This book features contributions from many of the leading international scientists from North America and Western and Eastern Europe who participated in this conference. Articles cover a broad range of hot topics in stem cell and leukemia research.
Mitochondria in Obesity and Type 2 Diabetes
Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers.
Lactate as a Major Signaling Molecule for Homeostasis
Topic Editor Dr. Philippe Connes has received a grant from HARTIS Pharma (Switzerland-France). All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Angiogenesis in Adipose Tissue
Angiogenesis has recently played a critical role in regulation of adipose tissue expansion and regression. Like most other tissues in the body, adipose expansion and regression is accompanied by alteration of blood vessel density and structures. The vascular alteration plays an active role in regulation of adipose tissue size and functions. Targeting blood vessels in the adipose tissue have demonstrated to be a novel approach for possibly treatment of cancer, obesity and other metabolic diseases. This book provides the most updated information on this type research and discusses future opportunities for therapy..
