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Reproductive and Hormonal Aspects of Systemic Autoimmune Diseases
This volume of the Handbook of Systemic Autoimmune Diseases series represents a medical collaboration focusing primarily on female aspects of rheumatic diseases. This collaboration recognizes the need to understand and optimally manage the care of women with autoimmune conditions that may affect their reproduction and hormonal status. This handbook will prove useful to clinicians and researchers alike. It covers practical points, ranging from which anti-rheumatic medications are safe in pregnancy to how to counsel women with scleroderma contemplating pregnancy. * Authors share an academic interest in the unique relationship between being a woman and having an autoimmune disease * Touches on controversial topics, such as the mechanism of antiphospholipid-related fetal loss and whether or not non-steroidal anti-inflammatory agents should be used in pregnancy * Includes critical and balanced reviews of the controversial association between autoimmune disease and female infertility
Infection and Autoimmunity
Infection and Autoimmunity encompasses the different mechanisms involved in the infection-autoimmunity association/induction. Special attention is given to heat shock proteins (HSPs) and to transgenic mouse models to better understand infection-induced autoimmunity. Organized into six parts, this book first discusses the mechanisms of autoimmune induction by infection. Some chapters follow discussing the vaccination and vaccines, including the controversial issue of vaccine-autoimmunity relationship. Other chapters elucidate the relationship of bacteria and parasites to autoimmunity. Lastly, the aspects of infections and diseases are described. This reference material will help readers gain a deeper insight into the important etiological aspects of autoimmunity. The only book directed at the interactions between infectious agents and autoimmunity Describes the prevalence and incidence of the global issues and current therapeutic approaches Presents the measures for infection control Completely updated, with new chapters One-stop reference with easy access to topics
The Skin in Systemic Autoimmune Diseases
This book represents the state-of-the-art in the field of skin and autoimmune rheumatic diseases. It covers systematically a growing and multifaceted topic which is of great importance in the clinical practice. It also serves as a sharp educational tool as each chapter provides summaries and specific highlights to key references cited into the text. The pathophysiological link between skin involvement and autoimmunity has been explained in detail, as well as diagnostic and therapeutic aspects. This book yields an impressive body of well ordered information which summarizes the experience of a selected panel of distinguished physicians and scientists actively involved in the field of skin immunology and systemic autoimmunity. * Written by a respected panel of distinguished physician-scientists actively involved in the field of skin immunology and systemic autoimmunity * Box summaries at the end of each chapter highlight important topics * Up-to-date basic knowledge as well as modern approach to diagnosis and therapy
Connective Tissue Disease
In this volume devoted to systemic lupus erythematosus (SLE) and Sjögren syndrome, leading specialists from different disciplines present the latest research findings on many aspects of the diseases and describe the most recent trends in treatment, such as the “treat to target” approach. Both basic science and clinical medicine are addressed, with emphasis on the most promising clinical and laboratory-based studies. The coverage is comprehensive in scope, encompassing, for example, epidemiology, pathogenesis, autoantibodies and biomarkers, disease manifestations, involvement of different organs or systems, relationships with other disorders, biological therapy of SLE, and systemic treatment of Sjögren syndrome. Readers will find this first volume of Connective Tissue Disease to be an excellent source of information on the current understanding of, and clinical approach to, SLE and Sjögren syndrome that clearly conveys the progress made in recent years.
Polynomial Chaos Methods for Hyperbolic Partial Differential Equations
This monograph presents computational techniques and numerical analysis to study conservation laws under uncertainty using the stochastic Galerkin formulation. With the continual growth of computer power, these methods are becoming increasingly popular as an alternative to more classical sampling-based techniques. The text takes advantage of stochastic Galerkin projections applied to the original conservation laws to produce a large system of modified partial differential equations, the solutions to which directly provide a full statistical characterization of the effect of uncertainties. Polynomial Chaos Methods of Hyperbolic Partial Differential Equations focuses on the analysis of stochas...
Active Subspaces
Scientists and engineers use computer simulations to study relationships between a model's input parameters and its outputs. However, thorough parameter studies are challenging, if not impossible, when the simulation is expensive and the model has several inputs. To enable studies in these instances, the engineer may attempt to reduce the dimension of the model's input parameter space. Active subspaces are an emerging set of dimension reduction tools that identify important directions in the parameter space. This book describes techniques for discovering a model's active subspace and proposes methods for exploiting the reduced dimension to enable otherwise infeasible parameter studies. Readers will find new ideas for dimension reduction, easy-to-implement algorithms, and several examples of active subspaces in action.
CIBO DI STRADA
Tutti lo vogliono, tutti lo chiedono: lo street food si sta prendendo la sua rivincita. Dopo anni di clandestinità, in tempi di crisi è tornato in voga il chiosco, da quello più spartano a quello di design del cuoco stellato. E allora pani ca' meusa, frittola, miasse, arancini, panini, panzerotti, lampredotto... Luca Iaccarino descrive i prodotti tipici di ogni regione d'Italia e propone una selezione dei posti più caratteristici dove gustarli, dopo averli provati "su strada". Una guida d'autore dove profumi, sapori e risparmio si uniscono a una grande vivacità di scrittura.
Appetiti
“Luca Iaccarino si è immerso nel mondo del cibo in tutte le declinazioni immaginabili, svelandoci le storie più belle, ma anche gli aspetti più discutibili. Ha raccontato ogni cosa con rigore, indagandone tutte le sfumature, inseguendo innovazioni e tendenze e rispondendo a ogni domanda che vi può passare per la testa, da quelle etiche a quelle pratiche.” (Dalla prefazione di Mario Calabresi).Ha fatto il cameriere nel più famoso ristorante del mondo (l’Osteria Francescana di Massimo Bottura) e traversato il Mediterraneo a bordo di una nave di cuochi; ha provato il “social eating” e raggiunto Virgilio Martinez nel suo ristorante a Moray in Perù, a 3600 metri, nella valle degli...
Il gusto delle piccole cose
Gli anni migliori della nostra vita e le gaffes che fanno sprofondare, gli incontri con le persone curiose e con quelle pazze, i dialoghi surreali con i bambini di quattro anni e una poesia dedicata alla parmigiana di melanzane, le radicali differenze tra una serata tra amiche e una tra amici, la lettera di insulti al capufficio (mai spedita) e le grandi categorie dell'umanità, l'atmosfera del vecchio bar e l'arancione del mangiadischi Penny, i lavori che si possono fare in mutande e un'ode ai vegani: "Il gusto delle piccole cose" è un centrifugato di vita, una raccolta di situazioni e riflessioni che ha un unico obiettivo: la riscoperta della spensieratezza. Centosessantadue raccontini che sono un balsamo per le ferite dei tempi difficili. Se una risata può seppellire, un sorriso può far risorgere.
