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Stochastic Regulation of the Interleukin-4 Gene
  • Language: en
  • Pages: 176

Stochastic Regulation of the Interleukin-4 Gene

This book focuses on the expression variability of highly regulated genes in multi-cellular organisms through a multidisciplinary approach combining quantitative measurements and mathematical modeling. For this purpose, the cytokine gene Interleukin-4 (IL-4) in murine type-2 (Th2) lymphocytes was chosen as prototypical model system of an inducible gene regulated at the epigenetic and transductional level. As many cytokines, IL-4 is expressed in a probabilistic manner, but the underlying molecular mechanisms behind this phenomenon are still unresolved. Through an iterative process of quantitative measurements and mathematical analysis, the author develops a computational model able to predict...

Experimental and Mathematical Analysis of Regulatory Networks in T-helper Lymphocytes
  • Language: en
  • Pages: 173

Experimental and Mathematical Analysis of Regulatory Networks in T-helper Lymphocytes

In this book, an interdisciplinary approach combining dynamic quantitative measurements with mathematical modelling is used to solve two different problems in molecular immunology. In the first part, structure and function of the gene-regulatory network that controls differentiation of type I T-helper (Th1) cells is investigated. By determining the network structure through an iterative process of modelling and experiments, the author shows that Th1 differentiation proceeds in two steps: In the early effector phase, the Th1 master transcription factor T-bet is controlled by an interferon-? dependent positive feedback loop, while in the later phase a second IL-12 dependent feedback maintains ...

Calendar of State Papers and Manuscripts Relating to English Affairs
  • Language: en
  • Pages: 760

Calendar of State Papers and Manuscripts Relating to English Affairs

  • Type: Book
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  • Published: 1897
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  • Publisher: Unknown

None

Frontiers in Gynecological Endocrinology
  • Language: en
  • Pages: 190

Frontiers in Gynecological Endocrinology

  • Type: Book
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  • Published: 2014-12-10
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  • Publisher: Springer

This volume offers an up-to-date overview on the major areas of gynecological endocrinology, presenting the latest advances in adolescent gynecological endocrinology, assisted reproduction, menstrual-related disorders, sexuality and transsexualism, polycystic ovary syndrome, myometrial pathology and adenomyosis, obesity and metabolic syndrome, hormonal contraception, premature ovarian failure and menopause. In each chapter the recent advances deriving from basic science and clinical investigations are related to the practical management of the condition under consideration, taking into account the need for individualized therapies. The book is published within the ISGE Book Series, a joint venture between the International Society of Gynecological Endocrinology and Springer and is based on the 2014 International School of Gynecological and Reproductive Endocrinology Winter Course. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women’s health as well as interested GPs.

Archaeology and Religion in Early Northwest India
  • Language: en
  • Pages: 289

Archaeology and Religion in Early Northwest India

  • Type: Book
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  • Published: 2015-08-12
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  • Publisher: Routledge

This book explores the ways in which past cultures have been used to shape colonial and postcolonial cultural identities. It provides a theoretical framework to understand these processes, and offers illustrative case studies in which the agency of ancient peoples, rather than the desires of antiquarians and archaeologists, is brought to the fore.

AACR 2022 Proceedings: Part B April 11-13
  • Language: en
  • Pages: 3696

AACR 2022 Proceedings: Part B April 11-13

The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.

Dynamics of the Il-2 Cytokine Network and T-cell Proliferation
  • Language: en
  • Pages: 114

Dynamics of the Il-2 Cytokine Network and T-cell Proliferation

This book adds to a intensively investigated question of immunological research. How do regulatory T cells mediate their function to ensure tolerance against self-antigen? The author analyzes the interaction via the cytokine interleukin 2 between T helper cells, which mediate immune responses, and regulatory T cells. Since both cell types depend on interleukin 2 to mediate their functions, competition for interleukin 2 is likely. A mathematical model is developed to describe the interaction. This model focuses on the interleukin 2 receptor dynamics on helper and regulatory T cells and the extracellular interleukin 2 diffusion. The interleukin 2 receptor dynamics is governed mainly by an auto...

Mathematical Modelling & Computing in Biology and Medicine
  • Language: en
  • Pages: 659

Mathematical Modelling & Computing in Biology and Medicine

None

Fifty-four
  • Language: en
  • Pages: 561

Fifty-four

  • Type: Book
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  • Published: 2005
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  • Publisher: Vintage

Intrigue, spying and paranoia, bizarre & cultly.