Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
The Glutamate/GABA-Glutamine Cycle
Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This...
Published Scientific Papers of the National Institutes of Health
Each issue lists papers published during the preceding year.
Preclinical and clinical issues in Alzheimer’s disease drug research and development
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called “amyloid cascade hypothesis”, amyloid-ß- peptide (Aß), produced by beta- and gamma- secretase-mediated cleavages of the amyloid precursor protein (APP), plays a pivotal role in the pathogenesis of AD. Aß was also shown to contribute to AD pathology by stimulating the hyperphosphorylation of tau which is responsible for the formation of neurofibrillary tangles. However, the “amyloid cascade hypothesis” was challenged by other theories which lend suppor...
Ganja Yoga
In this book, yoga teacher Dee Dussault brings the ancient tradition of using cannabis to enhance spiritual practice to a western audience. She describes the act of Ganja Yoga as a ceremony that makes conscious relaxation an intentional ritual that can be improved upon with practice. Dee Dussault is a certified yoga instructor and the first person to bring cannabis-enhanced yoga classes to North America. In Ganja Yoga, Dee walks readers through the considerations and best practices for introducing cannabis into your yoga practice, or infusing yoga into your smoking routine. It's equally useful for those who want to attend classes or use the book in the comfort of their own homes. Ganja Yoga will assist readers in how to: • Reap the benefits of profound relaxation • Assume an altered state in a safe, energizing way • Deepen the spiritual practice of yoga • Reconnect with the body using ancient techniques • Select the best setting, time, method of consumption, strains, poses and breathing techniques to ensure an excellent experience. Ganja Yoga isn't just a guide to mixing cannabis and exercise, it's a lifestyle practice for a more stress-free, harmonious world.
Preventing Suicide in Patients with Mental Disorders
Suicide is a complex phenomenon that is now considered understood as a neurodevelopmental condition encompassing childhood experiences as well as proximal conditions such as mental disorders and adverse life events. Individuals in crisis may face overwhelming psychological pain, which in some cases may overcome the threshold of each unique individual for whom suicide is considered the best option to deal with such pain. However, many socio-demographic, personal, or temperamental variables have been investigated for their causal association with suicide risk, but to date no single factor has clearly demonstrated an association with suicide. The mental disorders most frequently associated with suicide risk include bipolar disorders and major unipolar depression, substance use disorders and schizophrenia. However, anxiety, personality, eating, and trauma-related disorders, as well as organic mental disorders, also contribute to suicidal risk. Moreover, in modern society, the presence of social uncertainty, the changes in family models, the development of social media, and the loss of face-to-face interaction can have an impact on suicide risk, particularly in the younger generation.
