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CRISPR
“An excellent compendium of all things CRISPR from some of the leading minds in the field. With thorough coverage from every angle and beautifully detailed illustrations, this book is not to be missed!” Jennifer A. Doudna, Professor of Chemistry, Biochemistry & Molecular Biology, UC Berkeley; Founder, Innovative Genomics Institute; Nobel Laureate and coinventor of CRISPR technology “This journey through CRISPR biology and several of its breakthrough applications offers an exciting glimpse into one of the most beautiful and compelling fields in the life sciences.” David R. Liu, Director of the Merkin Institute at the Broad Institute of MIT and Harvard; Professor of Chemistry and Chemi...
Sortases, Transpeptidases that Anchor Proteins to the Envelope of Gram-positive Bacteria
The cell wall envelope of Gram-positive bacteria represents a surface organelle that functions not only as a cytoskeletal element for the physical integrity of microbes but also promotes interactions between bacteria and their environment. Most importantly for bacterial pathogens, as environments are subject to change, microbes respond with alterations in envelope structure and function. Bacterial cell wall assembly requires peptidoglycan precursors that together form a single large macromolecule, the murein sacculus, encircling the microbial cell with a 20-100 nm thick wall structure. Cell wall peptidoglycan is covalently and non-covalently decorated with teichoic acids, polysaccharides and...
The CRISPR/Cas System
The use of CRISPR/Cas technology for genome editing suggests many potential applications, including the alteration of the germline of humans, animals and food crops. The speed and efficiency of the CRISPR/Cas system make it a potentially useful system for gene therapy. In this volume expert international authors provide a useful and timely review of the applications of the CRISPR/Cas system across diverse fields and explore further avenues and research directions of this novel and powerful editing technology. The technology and its application are reviewed with respect to reproduction and development, immunity and genetic diseases, system structure and system specificity. Some of the potenti...
Biotechnology: Scientific Advancement Versus Public Safety
In this book, Dr Quintyn considers whether genetic engineering will exacerbate social injustices and/or lead to public safety issues. As designer babies mature, will they feel a sense of superiority or pass on mutations that negatively affect future generations? Should we ignore the risk of zoonotic (animal) diseases because they offer potential benefits for reducing organ shortages? Scientific advancement, if not guided responsibly and with public input, can be detrimental to public safety.This book is unique as it encompasses many biotechnologies within the definition of biotechnology. It gives a balanced view of biotechnology: its promise as evidenced in repairing mutations (i.e., genetic...
CRISPR-Cas Systems
CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.
Molecular Biology
The biological world operates on a multitude of scales - from molecules to tissues to organisms to ecosystems. Throughout these myriad levels runs a common thread: the communication and onward passage of information, from cell to cell, from organism to organism and ultimately, from generation to generation. But how does this information come alive to govern the processes that constitute life? The answer lies in the molecular components that cooperate through a series of carefully-regulated processes to bring the information in our genome to life. These components and processes lie at the heart of one of the most fascinating subjects to engage the minds of scientists today: molecular biology....
The Code Breaker -- Young Readers Edition
Walter Isaacson’s #1 New York Times bestselling history of our third scientific revolution: CRISPR, gene editing, and the quest to understand the code of life itself, is now adapted for young readers! When Jennifer Doudna was a sixth grader in Hilo, Hawaii, she came home from school one afternoon and found a book on her bed. It was The Double Helix, James Watson’s account of how he and Francis Crick had discovered the structure of DNA, the spiral-staircase molecule that carries the genetic instruction code for all forms of life. This book guided Jennifer Doudna to focus her studies not on DNA, but on what seemed to take a backseat in biochemistry: figuring out the structure of RNA, a clo...
Summary & Analysis of The Code Breaker
PLEASE NOTE: This is a summary and analysis of the book and not the original book. SNAP Summaries is wholly responsible for this content and is not associated with the original author in any way. If you are the author, publisher, or representative of the original work, please contact info[at]snapsummaries[dot]com with any questions or concerns. Walter Isaacson's latest bestselling biography follows the life and scientific achievements of Jennifer Doudna, the Nobel-Prize-winning biochemist who discovered the ability to edit the human gene. This summary of his 500-page tome offers a breakdown of the complicated science, the dozens of other scientists who contributed to the discovery, and the d...
The New Eugenics
The specter of early twentieth-century eugenics—with its goal of preventing the “unfit” from reproducing through forced sterilization—still haunts us in this era of genetic engineering. Conrad B. Quintyn, an associate professor of biological anthropology at Bloomsburg University, Bloomsburg, Pennsylvania, calls this the new eugenics era because geneticists have begun to explore ways to prevent and repair defective genes in all humans. In this book, he considers whether genetic engineering will exacerbate social injustices and/or lead to a public safety issue. For instance, in 2012, virologists in the U.S. and the Netherlands genetically engineered avian (bird) flu to be more transmis...
Modern Prometheus
This updated paperback edition contains all the very latest on the dramatic story of Crispr and the potential impact of this gene-editing technology.
