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Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS), which was described since 1869 by Jean Martin Charcot, is a devastating neurodegenerative disease characterized by the selective and progressive loss of upper and lower motor neurons of the cerebral cortex, brainstem and the spinal cord. The cognitive process is not affected and is not merely the result of aging because may occur at young ages. The only known cause of the disease is associated with genetic mutations, mainly in the gene encoding superoxide dismutase 1 (familial ALS), whereas there is no known cause of the sporadic form of ALS (SALS), which comprises >90% of cases. Both ALS types develop similar histopathological and clinical characteristic...
Neurobiology of Brain Disorders
Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second Edition provides basic scientists a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases. Topics include developmental, autoimmune, central, and peripheral neurodegene...
Frontier Road
Frontier Road uses the history of one road in southern Colombia—known locally as “the trampoline of death”—to demonstrate how state-building processes and practices have depended on the production and maintenance of frontiers as inclusive-exclusive zones, often through violent means. Considers the topic from multiple perspectives, including ethnography of the state, the dynamics of frontiers, and the nature of postcolonial power, space, and violence Draws attention to the political, environmental, and racial dynamics involved in the history and development of transport infrastructure in the Amazon region Examines the violence that has sustained the state through time and space, as well as the ways in which ordinary people have made sense of and contested that violence in everyday life Incorporates a broad range of engaging sources, such as missionary and government archives, travel writing, and oral histories
Glycine Neurotransmission
This dynamic field of research offers the exciting possibility for a better understanding of brain function. Presented here is an up-to-date review of the recent advances in basic research in the field. Topics covered include: the discovery of the neurotransmitter role of glycine; patch-clamp studies of glycine-gated chloride channels; the involvement of glycine in excitatory neurotransmission; antibodies and fixatives for the immunocytochemical localization of glycine; the anatomy, development, physiology and role of glycinergic neurons in the Xenopus embryo spinal cord; and immunocytochemistry of glycine and glycine receptors in the central auditory system.
Formation and Applications of the Sedimentary Record in Arc Collision Zones
"Inspired by a GSA Penrose Conference held in 2005 (cosponsored by the International Association of Sedimentologists and the British Sedimentological Research Group), the 17 papers in this volume explore sedimentary environments in arc collision zones and their utility in recording the evolution of modern and ancient convergent margins. The first set of papers in the collection focuses on formation and evolution of the sedimentary record in arc settings and arc collision zones, concentrating on modern intra-oceanic examples. Papers include studies of flexural modeling and factors that affect development of siliciclastic and carbonate deposits around modern arcs. The second half of the volume presents new applications of arc sedimentary records. These relate primarily to constraining tectonic events in the evolution of arc systems, but also concern the links among tectonic uplift, collision, and geomorphic and climatic feedback mechanisms in arc collision zones."--Publisher's website.
