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Targeting Ion Channels for Drug Discovery: Emerging Challenges for High Throughput Screening Technologies
Ligand and voltage-gated ion channels are highly regulated protein molecules that cross the cell membrane allowing ion flow from one side of the membrane to the other. They are ubiquitously expressed in human tissues and consist of one of the largest and best understood functional groups of proteins, with more than 400 members spanning nearly 1% of the human genome. They are involved in a variety of fundamental physiological processes, and their malfunction causes numerous diseases. In terms of the challenges faced in the effort to discover specific drugs in ancient and emerging diseases, ion channels are the third-largest class of target proteins after G-protein-coupled receptors (GPCRs) an...
Index-catalogue of Medical and Veterinary Zoology
Supplements 1-14 have Authors sections only; supplements 15- include an additional section: Parasite-subject catalogue.
Saline and Alkaline Soils in Latin America
This book provides the first comprehensive overview of saline and alkaline soils in Latin America, known for having one of the most extensive surface of salt-affected soils in the world. It is organized along two main axes: soils and vegetation. The book discusses the occurrence of such soils in the region, focusing mainly in management strategies for their sustainable use, and it presents accounts of natural vegetation and crops in the various environments of the region. Social impacts of such conditions and ongoing projects to overcome them are considered. Likewise, the book highlights physiological mechanisms that are responsible for the negative effects these soils exert on crops and forest resources and determine vegetation distribution in them. Plant breeding challenges and new perspectives for such environments are discussed. Technologies such as irrigation and drainage are included. The readership includes soil and plant scientists, as well as policy makers.
Politics, Propaganda and the Press
This book examines British and Argentine media output in the prelude to and during the 1982 Falklands/Malvinas Conflict and acknowledges the aftermath and legacies of the media response. Yards of ink have been spilt, reinforcing the view that the Argentine Junta’s action on 2nd April 1982 was a ‘diversion’ from domestic tensions. This view, coupled with the paucity of any thorough, in-depth analysis afforded to Argentine media aspects of the War - particularly the press - necessitates this volume’s copious international study of the Conflict. Uniquely, US media output is also analysed alongside Britain’s and Argentina’s, all drawing upon Cold War historiography and media theory, ...
Fiji Royal Gazette
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The Management of Industrial Forest Plantations
The Management of Industrial Forest Plantations. Theoretical Foundations and Applications provides a synthesis of current knowledge about industrial forestry management planning processes. It covers components of the forest supply chain ranging from modelling techniques to management planning approaches and information and communication technology support. It may provide effective support to education, research and outreach activities that focus on forest industrial plantations management. It may contribute further to support forest managers when developing industrial plantations management plans. The book includes the discussion of applications in 26 Management Planning in Actions boxes. These applications highlight the linkage between theory and practice and the contribution of models, methods and management planning approaches to the efficiency and the effectiveness of industrial plantations management planning.
