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Emerging Drugs and Targets for Multiple Sclerosis
Multiple sclerosis (MS) is a complex disease with a presumed autoimmune aetiology and few current effective treatments. Disease modifying therapies focus on the altering the natural course of relapsing and remitting MS, targeting the inflammatory response. Other targets involve tacking the cause of the disease – demyelination of axons through remyelination therapies. Due to several recent breakthroughs in the understanding of the pathophysiology of MS new targets for remyelination and immunomodulation are rapidly emerging. This book provides a comprehensive overview of drug discovery and development for the molecular basis of the disease, from new targets to drugs currently in clinical development, cellular and animal disease models to biomarkers for diagnosis and assessment in clinical trials. Emerging Drugs and Targets for Multiple Sclerosis is an ideal reference for any student or researcher interested in drug development for neurodegenerative diseases, autoimmune diseases and MS in particular.
Emerging Drugs and Targets for Multiple Sclerosis
Multiple sclerosis (MS) is a complex disease with a presumed autoimmune aetiology and few current effective treatments. Disease modifying therapies focus on the altering the natural course of relapsing and remitting MS, targeting the inflammatory response. Other targets involve tacking the cause of the disease – demyelination of axons through remyelination therapies. Due to several recent breakthroughs in the understanding of the pathophysiology of MS new targets for remyelination and immunomodulation are rapidly emerging. This book provides a comprehensive overview of drug discovery and development for the molecular basis of the disease, from new targets to drugs currently in clinical development, cellular and animal disease models to biomarkers for diagnosis and assessment in clinical trials. Emerging Drugs and Targets for Multiple Sclerosis is an ideal reference for any student or researcher interested in drug development for neurodegenerative diseases, autoimmune diseases and MS in particular.
Modernism, Rubén Darío, and the Poetics of Despair
Modernism, Ruben Darío, and the Poetics of Despair presents a detailed study of a neglected facet of Ruben Darío, and in general, of Hispanic Modernism: metaphysical and existential dimensions as preludes to Modernity. Alberto Acereda and J. Rigoberto Guevara approach the life and death issues in Darío works with special emphasis on his poetry. The authors demonstrate how the Nicaraguan poet takes the first steps towards poetic modernity. The tragic component of Darío works are examined in the light of Nineteenth Century philosophy, especially the work of Arthur Schopenhauer. Various thematic proposals are also formulated for the study of the works of Ruben Darío.
