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Tumour microenvironment in cancer research and drug discovery
The implication of tumour microenvironment (TME) on cancer progression and therapeutic response has profoundly shifted the paradigms of molecular cancer research and drug discovery. The intricate networks of immune-inflammatory cells and signalling, cancer-associated fibroblasts, endothelial cells and adipose cells are extensively researched for diagnostics, therapeutics and predictive values. This includes siRNA and miRNA nanotherapeutics targeting these molecular components, owing to their powerful gene-silencing properties. Despite the concerted effort in the development of drug targeting TME, such as BLZ945 (a colony-stimulating factor-1 receptor inhibitor), there is a void in clinically satisfactory drug to target this intricate factor, thus far.
Proceedings of the 2023 International Conference on Applied Psychology and Modern Education (ICAPME 2023)
This is an open access book. The 2023 International Conference on Applied Psychology, Modern Education (ICAPME 2023) was held in Kunming, China on 22–24 September 2023. The conference mainly focused on "applied psychology", "modern education" and other research fields to discuss. It aims to provide an international cooperation and exchange platform for experts and scholars in mental health and modern education and enterprise development to share research results, discuss existing problems and challenges, and explore cutting-edge technologies. The conference sincerely invites experts and scholars from domestic and foreign universities and research institutions to participate and authors to submit manuscripts to ICAPME 2023.
Bibliography and Index of Geology
Includes monthly abstracts and annual index.
Prominence and Locality in Grammar
This book challenges the current consensus on the analysis of wh-questions and reflexives from the perspective of the syntax-semantics interface. An integrated approach incorporating analyses of the interaction between different levels of linguistic knowledge is proposed. It argues that the derivation and interpretation of wh-questions and reflexives are not purely syntactic in nature but are regulated by principles operating at the syntax-semantics interface. Two general principles underlying our knowledge of language and cognition are proposed in this work. One is the Principle of Locality, and the other is the Principle of Prominence. It shows that although wh-quantification and reflexivi...
