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Os textos que se apresentam neste livro estão presentes no campo de pesquisas em Ciências Humanas que dialogam sobre conceitos, caminhos e propostas sobre Ciência, Arte e Vida, na prioridade de políticas públicas de formação do leitor, na formação de professores mediadores de leitura, na escola e na diversidade que a compõe.
This book focuses on central themes related to the conservation of bats. It details their response to land-use change and management practices, intensified urbanization and roost disturbance and loss. Increasing interactions between humans and bats as a result of hunting, disease relationships, occupation of human dwellings, and conflict over fruit crops are explored in depth. Finally, contributors highlight the roles that taxonomy, conservation networks and conservation psychology have to play in conserving this imperilled but vital taxon. With over 1300 species, bats are the second largest order of mammals, yet as the Anthropocene dawns, bat populations around the world are in decline. Greater understanding of the anthropogenic drivers of this decline and exploration of possible mitigation measures are urgently needed if we are to retain global bat diversity in the coming decades. This book brings together teams of international experts to provide a global review of current understanding and recommend directions for future research and mitigation.
Cellular DNA is constantly bombarded with environmental and chemical assaults that damage its molecular structure. In addition, the normal process of DNA replication is prone to error and may introduce mutations that can be passed to daughter cells. If left unrepaired, these DNA lesions can have serious consequences, such as cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the mechanisms that cells use to recognize and repair various types of DNA damage. Contributors discuss base excision repair, nucleotide excision repair, mismatch repair, homologous recombination, nonhomologous end joining, the SOS response, and oth...
Humans now wield a greater influence on the planet than any other species in history, and human-developed technologies like genetic engineering and artificial intelligence stand poised to overtake biological evolution. Just how did we arrive at this unique moment in human history, 14 billion years after the birth of the universe Sydney Brenner's 10-on-10: The Chronicles of Evolution brings together 24 prominent scientists and thinkers to trace the story of evolution through ten logarithmic scales of time. Through expert insights, this unique volume considers how humans found our place in the cosmos, and imagines what lies ahead.Published by Wildtype Books and distributed by World Scientific Publishing Co.
Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer. We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.
Molecular anthropology uses molecular genetic methods to address questions and issues of anthropological interest. More specifically, molecular anthropology is concerned with genetic evidence concerning human origins, migrations, and population relationships, including related topics such as the role of recent natural selection in human population differentiation, or the impact of particular social systems on patterns of human genetic variation. Organized into three major sections, An Introduction to Molecular Anthropology first covers the basics of genetics – what genes are, what they do, and how they do it – as well as how genes behave in populations and how evolution influences them. ...
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This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.