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Helicobacter pylori and Gastric Cancer
This volume explores in detail the molecular biology, genetics and immunology of the bacterium Helicobacter pylori that causes serious gastric diseases such as gastric cancer. The book provides in-depth insights into the mechanisms of H. pylori-induced pathogenicity, gives an overview of how the bacterium colonizes the human gut, how it manages to persist in the body and which factors play a role in the development of H. pylori-induced gastric cancer. Furthermore, the interaction between the Gram-negative bacterium and the human gut microbiome is explored, and clinical management and treatment strategies to combat gastric cancer are discussed. Helicobacter pylori is an extremely successful p...
Death in State Custody
What is expected of State authorities with regard to the obligation to safeguard the life of detainees? What obligations do State authorities have in relation to the investigation into deaths that occur during deprivation of liberty by the State? This book addresses these questions regarding death in State custody in view of the European Convention on Human Rights, in particular the right to life, the prohibition of torture and the right to respect for private life (including the right to self-determination). It also provides an analysis of whether the Dutch legal framework contains safeguards to meet the requirements that follow from the European Convention on Human Rights. Matters that are...
Induction Chemotherapy
Induction chemotherapy, as part of an integrated plan of management for locally advanced cancers, is being practiced throughout the world, but frequently teams are unaware of the work being undertaken in other institutions. This book aims to present the full range of management techniques used in induction chemotherapy within one accessible volume. It provides up-to-date information on pioneering and cutting edge practices and documents the advantages of integrated treatment schedules. Patient selection is discussed, and each of the cancer types for which induction therapy has proved important is considered in detail. All who are responsible for the treatment of patients with locally advanced cancers will find this book to be an invaluable source of information. It will be particularly interesting for specialist oncologists aiming to set up fully comprehensive cancer centers and for health administrators wishing to learn about the benefits of establishing such centers in strategic locations.
Mechanisms of Angiogenesis
Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected ...
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Image-Guided High-Precision Radiotherapy
This book equips readers with detailed knowledge on the current status of image-guided radiotherapy with photons and particles and highlights issues that need to be addressed in order to further improve treatment outcomes. The opening chapters cover clinical and technical aspects of target volume definition using anatomic (computed tomography and magnetic resonance imaging; MRI) as well as functional (MRI and positron emission tomography) imaging. Up-to-date information is then provided on the full range of image-guided high-precision radiotherapy techniques, including IMRT/VMAT, stereotactic body radiation therapy, MR-guided linear accelerators, MR-guided brachytherapy, and particle therapy...
Multiple Myeloma
Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy, including in particular the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.
Transanal Minimally Invasive Surgery (TAMIS) and Transanal Total Mesorectal Excision (taTME)
This book captures cornerstone developments in a new body of knowledge and provides an expert resource on a “hot topic” in rectal surgery. Transanal minimally invasive surgery (TAMIS) was designed for local excision of select rectal neoplasms, however soon it became realized that the TAMIS technique could be used for applications beyond local excision, most notably for transanal total mesorectal excision (taTME). This new operative technique has revolutionized our approach to the distal rectum by allowing for improved access, especially in obese male patients with an android pelvis, and by minimizing abdominal wall access trauma. The endpoints of improved oncologic resection, as defin...
Prioritization in Medicine
The gap between a rising demand for health care services on the one side and scarce resources on the other, is leading to a growing pressure on decision-making processes. Hence, prioritization in medicine has become an increasingly important issue for assuring stability of health systems and improving the capability of health care. The present volume addresses normative dimensions of methodological and theoretical approaches, the legal basis behind priority setting as well as international experiences concerning the normative framework and the process of priority setting. It also examines specific criteria for prioritization and discusses economic evaluations. Contributing authors from a broad range of scientific disciplines discuss prioritization within an international dialogue.
Multidisciplinary Management of Rectal Cancer
In this book, a distinguished group of clinicians provide straightforward, focused answers to the questions most commonly confronted by a multidisciplinary team when caring for patients with rectal cancer. The format of the book is designed to aid optimal decision making in a multidisciplinary setting with respect to key issues in imaging, radiotherapy, chemotherapy, and surgery, all of which are considered in detail. Helpful guidance is also offered on risk factor identification, pathology procedures and their prognostic value, and multidisciplinary team management. The authors have been carefully selected for their expertise, and most have been involved in the management of the more signif...
