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Excitatory Amino Acids
This past decade has led to many significant advances in the understanding of the function of excitatory amino acids in synaptic transmission. The cloning of the ionotropic and metabotropic glutamate receptor families of receptor proteins has produced new strategies for the pharmacological modulation of glutamate transmission. The engineering of transgenic animals with modified expression of receptor proteins has created new insights into the function, dysfunction and possible pathology causally related to glutamate receptors. Advances in the pharmacology of glutamate receptors has led to clinical research addressing multiple therapeutic applications of drugs that act on excitatory amino acid systems. A number of NMDA receptor anatagonists have now been studied in humans. AMPA/kainate and metabotropic receptor active compounds have left the preclinical realms of research and have moved towards or are in the clinic.
Designing Multi-target Drugs
Written by world-renowned experts, this is the first book to gather together knowledge and experiences of the rational discovery of multi-target drugs. It describes the current state of the art, the achievements, and the challenges of the field and lessons learned by researchers.
The Handbook of Stress
The Handbook of Stress: Neuropsychological Effects on the Brain is an authoritative guide to the effects of stress on brain health, with a collection of articles that reflect the most recent findings in the field. Presents cutting edge findings on the effects of stress on brain health Examines stress influences on brain plasticity across the lifespan, including links to anxiety, PTSD, and clinical depression Features contributions by internationally recognized experts in the field of brain health Serves as an essential reference guide for scholars and advanced students
Emerging Drugs and Targets for Parkinson's Disease
This exemplary new book reviews some of the most outstanding examples of new drugs currently in pharmaceutical development or new targets under the validation process to try to reach the Parkinson ́s drug market in the next few years as potential disease modifying drugs.
Diet, Brain, Behavior
As the field of nutritional neuroscience has grown, both the scientific community and the general population have expressed a heightened interest in the effect of nutrients on behavior. Diet, Brain, Behavior: Practical Implications presents the work of a diverse group of scientists who collectively explore the broad scope of research in the field.T
Pulmonary Arterial Hypertension
Pulmonary hypertension is a fatal lung and heart disease. It is characterized by shortness of breath, fatigue and fainting. It is exacerbated by an increase of the pressure in the lung vasculature through exercise, leading to progressive worsening of hemodynamics, right ventricular hypertrophy, right heart insufficiency and finally right heart failure. This book focuses on pulmonary arterial hypertension, a rare and progressive subgroup of pulmonary hypertension, which is today incurable and terminally faal. Classification of pulmonary arterial hypertension, its pathology, and strategies for future therapy will be of interest both to those suffering from the disease and those who take care of patients. This volume will also engage physicians and other scientists contributing to an understanding of the pathophysiology of pulmonary arterial hypertension and attempting to extend life of humans with pulmonary arterial hypertension by developing causal and curative therapies.
Nuclear Magnetic Resonance
As a spectroscopic method, nuclear magnetic resonance (NMR) has seen spectacular growth, both as a technique and in its applications. Today's applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive coverage of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules, which is covered in two reports: NMR of Proteins and Nucleic Acids and NMR of Carbohydrates, Lipids and Membranes. For those wanting to become rapidly aquainted with specific areas of NMR, Nuclear Magnetic Resonance provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an invaluable source of current methods and applications.
Essentials of Body MRI
Essentials of Body MRI extensively covers the field, offering clear and detailed guidance on MRI as an invaluable tool for the primary diagnosis and problem solving of diseases of the body, including the abdomen, liver, pancreas, pelvis, heart, urinary tract, and great vessels. The beginning chapters focus on the physics, pulse sequences, and other practical considerations related to body MR imaging, explained in an easy to understand way, to help the reader fully comprehend the imaging appearance of clinical disease. The remaining chapters discuss clinical applications, with topics spanning from the normal anatomic structures and diagnosis of abdominal, pelvic, cardiac, and vascular diseases to the modality's role as a tool for solving diagnostic problems. The key points of each chapter are boxed as Essentials to Remember for rapid review and learning. Written in clear, accessible text, and featuring 887 figures and numerous tables, Essentials of Body MRI is a resource that radiology residents, fellows, and anyone else who wants to learn about Body MRI, will turn to again and again.
MR Angiography of the Body
Magnetic resonance angiography (MRA) continues to undergo exciting technological advances that are rapidly being translated into clinical practice. It also has evident advantages over other imaging modalities, including CT angiography and ultrasonography. With the aid of numerous high-quality illustrations, this book reviews the current role of MRA of the body. It is divided into three sections. The first section is devoted to issues relating to image acquisition technique and sequences, which are explored in depth. The second and principal section addresses the clinical applications of MRA in various parts of the body, including the neck vessels, the spine, the thoracic aorta and pulmonary vessels, the heart and coronary arteries, the abdominal aorta and renal arteries, and peripheral vessels. The final section considers the role of MRA in patients undergoing liver or pancreas and kidney transplantation. This book will be an invaluable aid to all radiologists who work with MRA.
