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Pharmaceutical Residues in the Environment
Pharmaceuticals, due to their pseudo-persistence and biological activity as well as their extensive use in human and veterinary medicine, are a class of environmental contaminants that is of emerging concern. In contrast to some conventional pollutants, they are continuously delivered at low levels, which might give rise to toxicity even without high persistence rates. These chemicals are designed to have a specific physiological mode of action and to resist frequently inactivation before exerting their intended therapeutic effect. These features, among others, result in the bioaccumulation of pharmaceuticals which are responsible for toxic effects in aquatic and terrestrial ecosystems. It i...
Institutions and Organizations as Learning Environments for Participation and Democracy
This book discusses opportunities and limitations to democratic participation in institutions and organizations across the life course. It demonstrates that democratic participation is not something that is learned once and for all and applied in formal political settings, but something that is lived every day throughout life in various contexts. Institutions and organizations frame human lives and strongly determine the ability to participate and co-determine their communities. They are places for learning, deliberation and the development of the common good. The book conceptually and empirically analyses the potential of democratic participation within various institutions. The contributions range from early childhood institutions, schools, youth programs, workplaces, and vocational education to cultural organizations and nursing homes for the elderly. The book thereby provides a cross-sectional and interdisciplinary knowledge base to inspire future research and practical efforts to promote democratic participation within and across institutions around the world.
The Micronucleus Assay in Toxicology
Concerns about the adverse health effects of chemicals and radiation present in the environment and at workplaces have created the need for better detection systems to assess their potential to cause DNA damage in humans and other organisms across ecosystems. The Micronucleus Assay in Toxicology is the first comprehensive volume concerning the use of micronucleus assays in genetic toxicology. It succinctly explains the mechanisms by which genotoxins cause micronucleus formation and its relation to diseases. Furthermore, it describes the methods which are currently used for the analyses of micronuclei in different types of cells in human in vivo biomonitoring studies, routine in vivo tests wi...
Paediatric Formulation
The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Forensic Aspects of Paediatric Fractures
This excellently illustrated book, now in a revised and extended second edition, not only describes the radiological findings which can be found in child abuse cases but also places them in a forensic perspective – a crucial aspect often underrepresented in radiological books. The aim is to enable physicians involved in non-accidental trauma cases to interpret radiological findings in light of the forensic circumstances under which these findings have arisen. Accordingly, the book will assist in determining whether a fracture is accidental or the result of abuse. Fractures are addressed not only by anatomical location but also by trauma mechanism, with careful attention to evidence regardi...
