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Now in a revised second edition, this comprehensive text covers all aspects of male hypogonadism from the basic science to clinical management, comprehensively explaining and applying new insights to the treatment of hypogonadal men. Chapters covering neuroendocrine control of testicular function, Leydig cell function, spermatogenesis, and normal and delayed puberty open the book. The focus then turns to the pathophysiology and treatment of hypogonadism and other forms of testicular dysfunction, such as Klinefelter syndrome, cryptorchidism, and disorders of the pituitary, as well as reproductive and endocrine consequences of cancer treatment, environmental factors, obesity and aging. Next ar...
Clinical measurement of the therapeutic and adverse effects of a drug is an important part of drug evaluation and registration. This volume presents full coverage of the principles and practice of the measurement of drug effects in humans and its role in the evaluation and development of new drugs. Clinical interpretation and relevance of data, as well as the acceptability and accuracy of methodology are emphasized together with the special problems of the cardiovascular system and the central nervous system. Contributions are from an international team of scientists and clinicians from both academia and industry. Clinical Measurement in Drug Evaluation will be useful for clinical and research scientists, research-based pharmacologists, and the pharmaceutical industry.
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The Fourth International Conference on Ion Implantation: Equipment and Tech niques was held at the Convention Center in Berchtesgaden, Bavaria, Germany, from September 13 to 17, 1982. It was attended by more than 200 participants from over 20 different countries. Severa1 series of conferences have dealt with the app1ication of ion implantation to semiconductors and other materials (Thousand Oaks, 1970; Garmisch-Partenkirchen, 1971; Osaka, 1974; Warwick, 1975; Bou1der, 1975; Budapest, 1978; and Albany, 1980). Another series of conferences has been devoted to implantation equipment and techniques (S- ford, 1977; Trento, 1978; and Kingston, 1980). This conference was the fourth in the 1atter se...
This book constitutes the refereed proceedings of the 14th Pacific Rim Conference on Artificial Intelligence, PRICAI 2016, held in Phuket, Thailand, in August 2016. The 53 regular papers and 15 short papers presented in this volume were carefully reviewed and selected from 161 submissions. Pricai covers a wide range of topics such as AI foundations; applications of AI; semantic web; information retrieval; constraint satisfaction; multimodal interaction; knowledge representation; social networks; ad-hoc networks; algorithms; software architecture; machine learning; and smart modeling and simulation.