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Complete Atlas of the World
Complete Atlas of the World is the ultimate insight into our planet and the clearest, most concise overview of the world's geography. This incredible guide showcases locations from Boston to Bangkok and beyond with over 330 maps, including over 100 city plans, to truly bring these landscapes to life. Complete Atlas of the World is the definitive look at the world we live in. Detailed terrain models and colour schemes offer accessible mapping of unsurpassed quality. Complete Atlas of the World is now fully revised and updated to reflect recent geopolitical changes such as the new nation of South Sudan and the annexation of Crimea. Understand the fascinating world in which we live with this fantastic resource. Previous edition ISBN 9781405394413
Exocytosis and Endocytosis
In this book, skilled experts provide the most up-to-date, step-by-step laboratory protocols for examining molecular machinery and biological functions of exocytosis and endocytosis in vitro and in vivo. The book is insightful to both newcomers and seasoned professionals. It offers a unique and highly practical guide to versatile laboratory tools developed to study various aspects of intracellular vesicle trafficking in simple model systems and living organisms.
Autophagy
Starting in the early 1970s, a type of programmed cell death called apoptosis began to receive attention. Over the next three decades, research in this area continued at an accelerated rate. In the early 1990s, a second type of programmed cell death, autophagy, came into focus. Autophagy has been studied in mammalian cells for many years. The recen
Protein Blotting and Detection
Over the past thirty years, the development of the Western blot has revolutionized the fields of biomedical research and medical diagnostics. In "Protein Blotting and Detection: Methods and Protocols", expert researchers present numerous techniques based on the Western blot, providing detailed, readily reproducible methods, tips, and alternatives directly and easily transferable to the laboratory setting. Chapters offer a large number of variations on the theme of protein transfer to solid support followed by detection, presenting both adaptations of traditional techniques as well as completely original methods of protein blotting. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, a list of necessary materials, step-by-step methods, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Innovative and highly practical, Protein Blotting and Detection: Methods and Protocols is an essential, hands-on guide for all investigators who hope to bring these cutting-edge procedures home to their laboratories.
After Europe
A impassioned defense of the European Union and a concise analysis of its present challenges and future In this provocative book, renowned public intellectual Ivan Krastev reflects on the future of the European Union—and its potential lack of a future. With far-right nationalist parties on the rise across the continent and the United Kingdom planning for Brexit, the European Union is in disarray and plagued by doubts as never before. Krastev includes chapters devoted to Europe's major problems (especially the political destabilization sparked by the more than 1.3 million migrants from the Middle East, North Africa, and South Asia), the spread of right-wing populism (taking into account the election of Donald Trump in the United States), and the thorny issues facing member states on the eastern flank of the EU (including the threat posed by Vladimir Putin's Russia). In a new afterword written in the wake of the 2019 EU parliamentary elections, Krastev concludes that although the union is as fragile as ever, its chances of enduring are much better than they were just a few years ago.
Dictionary of Cognitive Science
Presents comprehensive definitions in more than 120 subjects. Topics range from 'Abduction' to 'Writing' within the domains of psychology, artificial intelligence, neuroscience, philosophy, and linguistics.
The Prion Protein
A conformational transition of the cellular prion protein (PrPC) into an aberrantly folded isoform designated scrapie prion protein (PrPSc) is the hallmark of a variety of neurodegenerative disorders collectively called prion diseases. They include Creutzfeldt-Jakob disease and Gerstmann-Stäussler-Scheinker syndrome in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and chronic wasting disease (CWD) in free-ranging deer. In contrast to the deadly properties of misfolded PrP, PrPC seems to possess a neuroprotective activity. More-over, animal models indicated that the stress-protective activity of PrPC and the neurotoxic effects of PrPSc are somehow interconnected....
New Reflections on Grammaticalization
The contributions in this volume cover a wide range of theoretical and methodological issues and raise a number of new questions that indicate the future direction of grammaticalization studies. The volume focuses on issues such as grammaticalization and lexicalization; the unidirectionality hypothesis; the issue of the relevance of contexts for grammaticalization; the description of grammaticalization paths. Much of the current work concentrates on such categories, as discourse markers, honorifics or classifiers, which have not previously been central to works on grammaticalization. Other studies take a new perspective on known grammaticalization paths by applying concepts adopted from other linguistic fields, such as prototype theory, morphocentricity, or by discussing their findings from a comparative or typological angle, presenting data from a large number of languages, often based on extensive empirical investigations of written and spoken text corpora.
Ferroptosis in Health and Disease
This updated and expanded volume gives new insights on ferroptosis – an iron-dependent form of non-apoptotic cell death. The collection of chapters discusses the two major pathways through which ferroptosis can occur: the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway. Readers will gain an understanding of the multiple levels, on which this special cell death is regulated. Hence, the contributions will take a closer look at epigenetic, transcriptional, posttranscriptional and posttranslational layers. Among the described regulators and transcription factors are GPX4, ACSL4 and NFE2L2. This edited volume collects reviews related to current knowledge on the integrated molecular machinery of ferroptosis, thereby also describing how dysregulated ferroptosis is involved in human diseases.
