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Trends in Drug Research II
This volume of Pharmacochemistry Library comprises the text of invited lectures presented at the 11th Noordwijkerhout-Camerino Symposium Trends in Drug Research, held in Noordwijkerhout, The Netherlands, from 11-15 May 1997. In the programme attention has been given to the generation of new biological target systems and the generation of new lead molecules, with presentations on e.g. combinatorial chemistry, compound libraries, database search, high throughput screening and molecular biology. Other topics discussed were the perspectives for new medicines for the gastro-intestinal tract, the major developments in the search for effective anti-HIV drugs and new aspects in synthetic approaches. In a special session three topics which currently draw much attention were discussed: How to deal with the major problem of resistance against antimirobial agents? Can the apoptosis mechanism be used as a drug target? Is the newly observed phenomenon of inverse agonism a general principle and has it consequences for drug development (and use?)
A Systems Biology Approach to Study Metabolic Syndrome
The aim of this book is to provide the target audience, specifically students of Medicine, Biology, Systems Biology and Bioinformatics, as well as experienced researchers in research fields relevant to metabolic syndrome (MetS) with an overview of the challenges and opportunities in systems biology and how it can be used to tackle MetS. In particular, the aims are: (1) to provide an introduction to the key biological processes involved in the pathophysiology of MetS; (2) through the use of specific examples, provide an introduction to the latest technologies that use a systems biology approach to study MetS; and (3) to give an overview of the mathematical modeling approaches for studying MetS. The clearly written chapters by leading experts in the field provides detailed descriptions crucial for the unique position of this book and its focus on the application of systems biology to tackle specific pathophysiologically relevant aspects of MetS and provides a valuable practical guide to this research community.
Flexible Automation and Intelligent Manufacturing: Establishing Bridges for More Sustainable Manufacturing Systems
This book reports on cutting-edge research and developments in manufacturing, giving a special emphasis to solutions fostering automation, sustainability and health, safety and well-being at work. Topics cover manufacturing process analysis and optimization, supply chain management, quality control, as well as human factors and logistics. They highlight the role and advantages of intelligent systems and technologies, discussing current best-practices and challenges to cope with in the near future. Based on proceedings of the 32nd edition of the International Conference on Flexible Automation and Intelligent Manufacturing, FAIM 2023, held on June 18–22, 2023, in Porto, Portugal, this second volume of a 2-volume set provides academics and professionals with extensive information on innovative strategies for industrial management in the era of industry 5.0.
Transdisciplinary Engineering for Complex Socio-technical Systems – Real-life Applications
Transdisciplinary engineering transcends other inter- and multi-disciplinary ways of working, such as Concurrent Engineering (CE). In particular, transdisciplinary processes are aimed at solving complex, ill-defined problems, or problems for which the solution is not immediately obvious. No one discipline or single person can provide sufficient knowledge to solve such problems, so collaboration is essential. This book presents the proceedings of the 27th ISTE International Conference on Transdisciplinary Engineering, organized by Warsaw University of Technology, Poland, from 1-10 July 2020. ISTE2020 was the first of this conference series to be held virtually, due to the COVID-19 restriction...
Managing Technology Integration for Human Resources in Industry 5.0
Although the transition between the first three industrial revolutions took more than a century, Industry 4.0 is progressing quickly. The emergence of digitalization has been rapid thanks to the development of cutting-edge technologies. Though we are witnessing this rapid technological decentralization and interconnectivity at present, organizations and researchers are already discussing Industry 5.0 where full integration of the human side of business and intelligent systems is expected. In this scenario, it is essential to look forward to such strategic workplaces that allow a combination of humans and technology to assure a high degree of automation merged with the cognitive skills of bus...
Marine Natural Products
This book is a compilation of the latest achievements of leading researchers in marine natural products with extremely diverse structures and biological activities. It presents discussions of isolation, structure elucidation, biosynthesis, total synthesis, and biochemical properties of the compounds with characteristic structures such as macrolides, cyclic depsipeptides, alkaloids, and water-soluble heterocyclic low-molecular-weight compounds, from sponges, bacteria, cyanobacteria, flagellates, and other such organisms. The book especially focuses on heterocyclic natural products as a title in the book series, Topics in Heterocyclic Chemistry.
Bile Acids and Their Receptors
This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.
Interventional Psychiatry
Recent advances in pharmacology and brain stimulation have led to the development of novel treatments for psychiatric disorders. These new advances have led to the development of a new subspeciality, Interventional Psychiatry. Interventional Psychiatry: Road to Novel Therapeutics reviews all specialized treatments including device-based interventions such as electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), and deep brain stimulation (DBS). This book discusses the procedure-based pharmacologic interventions including ketamine infusion therapy and psychedelic therapies. Internationally contributed, each this book outlines the state of the field, as well as implications for training and the role of the interventional psychiatrist in treatment teams. - Introduces an innovative approach combining both well-established and innovative methodologies - Includes an in-depth description of putative mechanisms of action - Features clinician-friendly presentation of indications, contraindications, and techniques - Outlines guidelines to foster fellowships in Interventional Psychiatry
Transdisciplinary Engineering Methods for Social Innovation of Industry 4.0
The concept of concurrent engineering (CE) was first developed in the 1980s. Now often referred to as transdiciplinary engineering, it is based on the idea that different phases of a product life cycle should be conducted concurrently and initiated as early as possible within the Product Creation Process (PCP). The main goal of CE is to increase the efficiency and effectiveness of the PCP and reduce errors in later phases, as well as incorporating considerations – including environmental implications – for the full lifecycle of the product. It has become a substantive methodology in many industries, and has also been adopted in the development of new services and service support. This bo...
Selected Topics in DNA Repair
This book is intended for students and scientists working in the field of DNA repair, focusing on a number of topics ranging from DNA damaging agents and mechanistic insights to methods in DNA repair and insights into therapeutic strategies. These topics demonstrate how scientific ideas are developed, tested, dialogued, and matured as it is meant to discuss key concepts in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.
