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Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Old age is associated with a number of medico-social problems such as: hypertension, diabetes mellitus, thyroid disorders, osteoarthritis, tremor, pain, gait and balance impairment, incontinence, urinary tract infection, sarcopenia, osteoporosis, polypharmacy, pressure ulcers, sleeping problems, cardiocerebrovascular disorders, fluid and electrolyte disturbance, nutritional disorders, immunisation and disease prevention rehabilitation and care. The management of these problems differs significantly between younger and older adults. All of these problems are evaluated in this book in two parts with the contributions of experienced clinicians and researchers. In addition, cellular ageing, comprehensive geriatric assessments, and medicolegal and ethical principles in geriatric medicine are also evaluated. This book will be a valuable tool for all clinicians involved in the management of elderly people.
Taurine, or 2aminoethanesulfonic acid, is one of the most abundant sulfurcontaining amino acids in the human body. It is found in the heart, brain, retina, and skeletal muscles, and is synthesized in the pancreas. Studies have revealed that taurine is of high physiological importance: it protects against pathologies associated with mitochondrial diseases, and linked processes like aging, metabolic syndrome, cancer, cardiovascular diseases, and neurological disorders. It is also used as a nutritional supplement. Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases explores the significance of taurine in the biology of mitochondria. It also explains its role as ...
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Rumi’s Sun collects many lessons and discourses from Shams of Tabriz, the Sufi mystic and spiritual master who was the catalyst for Rumi’s awakening. His teachings and insights inspired much of Rumi’s poetry and are still celebrated today by all Sufi. Translated by two noted students of Sufi, Shams’ timeless teachings are presented here in their traditional order. Through the book, readers discover the teachings that made Rumi dance and gain access into Sufi traditions and the power of mystical love.