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This volume is THE definitive, completely up-to-date, reference work for ALL researchers and clinicians working in autoimmunity.Up-to-Date: This is a timely critical review of more than 100 autoantibodies by leading experts in their respective fields, and includes many recent references.International Experts: The 120 Chapters have been written by the top international cadre of authors who have provided structured, expert contributions.Comprehensive: A total comprehensive perspective on the processes which induce, inhibit or otherwise affect autoantibodies in humans.Useful to Researchers and Clinicians: Chapters generally include methods of detection, pathogenic role, factors in pathogenicity and genetics as well as clinical utility with disease associations and frequencies.
This collection of essays on diverse issues in collaborative work illuminates the next direction for the study and practice of collaboration in classrooms and research projects. The essays probe more deeply than any previous work into the political, social, and individual psychologies of students, teachers, and researchers working together. Beginning with a critique of the ideology of individualism, the authors treat classroom issues at all levels from middle school through graduate school. Advocating an affirmative philosophy of collaboration, the authors attempt to understand both its shortcomings and its successes, as illustrated in many examples of essays and comments written by students in collaborative projects.
The maturation of the precursors of mRNA to a functional transcript in eukaryotic cells is a complex, multistep process. It includes the formation of RNP complexes and the splicing procedure. Also, the presence of snRNA packaged as snRNP particles plays an important role in this process. In addition, snRNPs are involved in various autoimmune diseases in which autoantibodies are directed against components of these particles. Relevant techniques to investigate RNA processing, splicing, protein-RNA complex formation and protein-RNA interactions as well as the use of autoantibodies in basic and clinical research are presented in this manual.
Describes general aspects of metals in clinical chemistry focusing not only on the physiology of metal ions and their analytical determination in biological materials, but also on their geochemical distribution, technical uses and environmental effects.
The concept of flow injection analysis (FIA) was introduced in the mid-seventies. It was preceded by the success of segmented flow analysis, mainly in clinical and environmental analysis. This advance, as well as the development of continuous monitors for process control and environmental monitors, ensured the success of the FIA methodology. As an exceptionally effective means of mechanization for various procedures of wet chemical analysis, the FIA methodology, in use with a whole arsenal of detection methods of modern analytical chemistry, proved to be of great interest to many.The fast and intensive development of the FIA methodology was due to several factors essential for routine analyt...
Advances in Protein Chemistry
Scholarship on NATO is often preoccupied with key episodes in the development of the organisation and so, for the most part, has remained inattentive to theory. This book addresses that gap in the literature. It provides a comprehensive analysis of NATO through a range of theoretical perspectives that includes realism, liberalism and constructivism, and lesser-known approaches centred on learning, public goods, securitisation and risk. Focusing on NATO’s post-Cold War development, it considers the conceptualisation, purpose and future of the Alliance. This book will be of interest to students and scholars of international organisation, international relations, security and European Politics.
Beer in Health and Disease Prevention is the single comprehensive volume needed to understand beer and beer-related science. Presenting both the concerns and problems of beer consumption as well as the emerging evidence of benefit, this book offers a balanced view of today's findings and the potential of tomorrow's research. Just as wine in moderation has been proposed to promote health, research is showing that beer – and the ingredients in beer – can have similar impact on improving health, and in some instances preventing disease. This book addresses the impact of beer and beer ingredients on cancers, cardiovascular disease, anti-oxidant benefits, and other health related concerns. It...