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Oligonucleotides as Therapeutic Agents
The use of oligonucleotides as therapeutic agents rests upon their ability to interfere, in a sequence-specific manner, with the fundamental machinery of protein synthesis either by binding to the mRNAs transcribed from a gene or by binding directly to a target gene. This approach can be used not only for inhibition of the synthesis of host proteins but also of those required by invading pathogens. Potential therapeutic applications are enormous, ranging over hypertension, cardiovascular disease, autoimmune disease, vital and other parasitic infections (especially HIV), and cancer. This book discusses the chemistry and pharmacokinetics of oligonucleotides and their analogues, and surveys the results of structure-activity studies and current clinical trials. It also critically reviews the problems with antisense therapy, such as the enzymatic destruction of oligonucleotides, the doses required for a therapeutic response, the difficulty in directing oligonucleotides to particular target tissues and cells, the need for parenteral administration, and doubts concerning the mechanism of action (especially problems associated with non-specific binding to proteins) and long-term effects.
Late in an Angler's Life
This collection of musings by well-known literary fisherman Gordon Wickstrom uses fishing as a lens through which to view and evaluate most things in life: politics, art, friendship, religion, globalization, relations between the sexes, time, seasonality, and old age.
The TBE Book
While the number of vector-borne diseases and their incidence in Europe is much less than in tropical and/or developing countries, there are nevertheless a substantial number of such infections in Europe. The most important one is the zoonotic arbovirus infection Tick-Borne Encephalitis (TBE), a virus transmitted to humans by ticks or by consumption of unpasteurized dairy products from infected cows, goats, or sheep. TBE is endemic in the non-tropical Eurasian forest belt with most cases occurring in Russia and in central and eastern parts of Europe. In endemic areas, TBE is one of the most important causes of viral meningitis/encephalitis and a major public health concern. Moreover, TBE is ...
The Molecular Basis of Human Cancer
This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.
Seafood and Freshwater Toxins
This volume focuses on the pharmacology, physiology, toxicology, chemistry, ecology and economics of seafood and freshwater toxins. It covers the biological aspects of the bloom, the effects and actions of each toxin with emphasis on human aspects, and the analytical and preparative options for neurotoxic, diarrhetic shellfish toxins, and hepatotox
G Protein Coupled Receptors
This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high throughput assays for identification of pharmacoperone drugs. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers G protein coupled receptors - Contains chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high-throughput assays for identifying pharmacoperone drugs
Communicating Prognosis
This text centres on practical discussions with family members of patients who suffered a neurocatastrophy. The book summarizes current data on outcome in acute neurologic conditions. It provides guidance in family conferences and how to best convey prognosis. Conflict resolution and how to proceed with palliative care is also discussed.
Feigin and Cherry's Textbook of Pediatric Infectious Diseases - E-Book
Widely considered the premier text in pediatric infectious diseases, Feigin and Cherry's Textbook of Pediatric Infectious Diseases, 9th Edition, provides authoritative, up-to-date coverage of this rapidly changing field. Extensively revised by Drs. James Cherry, Sheldon L. Kaplan, Gail J. Demmler-Harrison, William J. Steinbach, Peter J. Hotez, and new editor John V. Williams, this two-volume reference delivers the information you need on epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. It serves as a reliable, everyday resource for practicing ID specialists, and an invaluable reference for medical students, residents, and fellows...
