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Negative Regulators of Innate Immunity and their Role in Host Responses to Injury and Infection, 2nd edition
Every organism must recognize damage-associated and pathogen-associated molecular patterns (DAMPs and PAMPs) to react rapidly. The immune system requires potent negative regulators to control unnecessary or overshooting responses and balance the homeostasis in all tissues. A significant number of negative regulators of pattern recognition receptors (PRR) consist of modified innate sensors and downstream molecules that regulate inflammatory signals initiated by sterile, damage-associated inflammation as well as responses to pathogens. These conserved mechanisms contribute to immune homeostasis, maintain a constant number of immune cells, and limit the activation of the cells during frequent s...
Dictionary of American Family Names
Where did your surname come from? Do you know how many people in the United States share it? What does it tell you about your lineage? From the editor of the highly acclaimed Dictionary of Surnames comes the most extensive compilation of surnames in America. The result of 10 years of research and 30 consulting editors, this massive undertaking documents 70,000 surnames of Americans across the country. A reference source like no other, it surveys each surname giving its meaning, nationality, alternate spellings, common forenames associated with it, and the frequency of each surname and forename. The Dictionary of American Family Names is a fascinating journey throughout the multicultural United States, offering a detailed look at the meaning and frequency of surnames throughout the country. For students studying family genealogy, others interested in finding out more about their own lineage, or lexicographers, the Dictionary is an ideal place to begin research.
Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses
Nano- and microparticles including crystals, synthetic biomaterials, misfolded proteins or environmental particulates are involved in a wide range of biological processes and diseases. They may present as intrinsic or environmental toxins but may also be applied intentionally, e.g. as immune adjuvants, drug carriers or ion exchangers. The discovery that a wide range of nano- and microparticles share the capacity to induce IL-1β secretion via activation of the NLRP3 inflammasome in dendritic cells and macrophages has led to the hypothesis that nano- and microparticles may contribute in a uniform mechanistic manner to different disease entities. Other molecular mechanisms triggered by a range...
Anion Carriers of Mitochondrial Membranes
In order to provide a functional organisation of the various biochemical processes, the intracellular environment is subdivided into compartments formed by organelles. Mitochondria serve to restore energy-rich compounds, while energy is mainly consumed in the cytosolic space. Molecules involved in these metabolic cycles have to cross the mitochondrial membrane via specialized carriers embedded in the inner mitochondrial membrane. All relevant structural and functional aspects of the Anion Carriers of Mitochondrial Membranes as well as isolation procedures, reconstitution experiments and biogenesis of the carriers, kinetics of transport as well as the metabolic regulation mechanisms are treated in this volume.
