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Philosophy of Molecular Medicine
Philosophy of Molecular Medicine: Foundational Issues in Theory and Practice aims at a systematic investigation of a number of foundational issues in the field of molecular medicine. The volume is organized around four broad modules focusing, respectively, on the following key aspects: What are the nature, scope, and limits of molecular medicine? How does it provide explanations? How does it represent and model phenomena of interest? How does it infer new knowledge from data and experiments? The essays collected here, authored by prominent scientists and philosophers of science, focus on a handful of mainstream topics in the philosophical literature, such as causation, explanation, modeling, and scientific inference. These previously unpublished contributions shed new light on these traditional topics by integrating them with problems, methods, and results from three prominent areas of contemporary biomedical science: basic research, translational and clinical research, and clinical practice.
Sadness or Depression?
The World Health Organization states that depression is the leading cause of disability worldwide, and predicts that by 2030 the epidemic of depression raging across the world will be the single biggest contributor to the overall burden of disease of all health conditions. Yet this gloomy picture masks a number of paradoxes concerning the diagnosis and cultural interpretation of depression that appear to challenge the claimed prevalence rates on which it is based. This book’s essays by some of the world’s leading researchers and scholars on depression explores these anomalies in detail from multidisciplinary and multicultural perspectives, and in doing so reshapes the debate on the natur...
Uncertainty in Pharmacology
This volume covers a wide range of topics concerning methodological, epistemological, and regulatory-ethical issues around pharmacology. The book focuses in particular on the diverse sources of uncertainty, the different kinds of uncertainty that there are, and the diverse ways in which these uncertainties are (or could be) addressed. Compared with the more basic sciences, such as chemistry or biology, pharmacology works across diverse observable levels of reality: although the first step in the causal chain leading to the therapeutic outcome takes place at the biochemical level, the end-effect is a clinically observable result—which is influenced not only by biological actions, but also p...
Explaining Disease: Philosophical Reflections on Medical Research and Clinical Practice
This interdisciplinary monograph in philosophy of medicine examines models of explanation in health science and their relation with current medical trends, such as personalized and person-centered medicine. Medicine has provided challenging case studies for the general philosophy of science that have prompted rethinking of a wide range of philosophical notions – such as scientific law, theory and evidence – and contributed to the elaboration of pluralistic approaches to modeling, causality and explanation. The health sciences have increasingly recognized the role of philosophy of medicine as both a field of conceptual and methodological reflection, capable of addressing practical issues,...
The Indoctrinated Brain
Global War on the Human Brain Throughout the world, mental capacity is declining, especially among young people, while depression rates are rising dramatically. Meanwhile, one in forty men and women suffers from Alzheimer's, and the age of onset is falling rapidly. But the causes are not being eliminated, quite the opposite. Can this just be coincidence? The Indoctrinated Brain introduces a largely unknown, powerful neurobiological mechanism whose externally induced dysfunction underlies these catastrophic developments. Michael Nehls, medical doctor and internationally renowned molecular geneticist, lays out a shattering chain of circumstantial evidence indicating that behind these numerous ...
Defining Mental Disorder
Philosophers discuss Jerome Wakefield's influential view of mental disorder as "harmful dysfunction," with detailed responses from Wakefield himself. One of the most pressing theoretical problems of psychiatry is the definition of mental disorder. Jerome Wakefield's proposal that mental disorder is "harmful dysfunction" has been both influential and widely debated; philosophers have been notably skeptical about it. This volume provides the first book-length collection of responses by philosophers to Wakefield's harmful dysfunction analysis (HDA), offering a survey of philosophical critiques as well as extensive and detailed replies by Wakefield himself.
The Fragility of Philosophy of Medicine
This book about philosophy of medicine bestows a bottom-up and not a top-down approach. It starts from clinical medicine and epidemiology, analyzing their interrelations with philosophical instruments. The book criticizes the constant search for generalities and the essentialism that too often characterizes this discipline, which results in philosophers of medicine dialoguing with each other without direct contact with medical science. In the light of Ludwig Wittgenstein's philosophy, this book proposes an approach to the philosophy of medicine based on the quorum of language, what Wittgenstein calls family resemblances. In this way the author establishes a philosophy of medicine that is closely related to the medical clinic and to public health and as such avoids armchair philosophy. “Don’t think, but look", wrote Wittgenstein.
Vice and Psychiatric Diagnosis
Vice and Psychiatric Diagnosis begins with the simple question of why some categories of mental disorder include immoral or criminal conduct as diagnostic features, while most mental disorders in the DSM and ICD do not involve such "vice-laden" concepts. While this initial puzzle seems to concern only the limited domain of psychiatric nosology, Sadler's expansive scholarship reveals that this simple question leads inexorably to complex questions about the role of "madness and morality" in intellectual history, and to today's many conflicts and contradictions in the policy and culture of mental health, criminal justice, and related social welfare efforts. The book outlines the implications of...
Reconsidering Medicine
This is an original book on the philosophy of medicine. It considers philosophy of medicine as a subdiscipline of philosophy of science. This volume is grounded on an epistemological bottom-up account that arises from the clinical situation, the epidemiologic, and the resulting public health account. It is not a review of the literature, and it is not intended to frame the debates, or to analyze and compare the various number of viewpoints. Medicine is the human activity, which begins by a linguistic act that identifies the negative norms of health: it begins with a first distinction that splits biological processes into three conventional parts, normal, abnormal and pathologic. Neither of t...
