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HIV I: Molecular Biology and Pathogenesis: Clinical Applications
The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, ...
Treatment of Leukemia and Lymphoma
New Treatments of Leukemia and Lymphoma describes the most important advances in the therapy of hematopoietic cancers that have been derived from recent discoveries in cancer cell biology, kinase biochemistry, and immunology. Detailed descriptions of the large number of new and effective agents that have recently become available for the treatment of leukemias and lymphomas as well as an understanding of their mechanisms of action and their integration into current therapy are provided. A number of experimental drug reagents currently in clinical investigation are also discussed. The therapies include conventional anti-metabolites, monoclonal antibodies directed to cell surface receptors, an...
Amylin
Amylin deciphers amylin's physiology and reveals previously unrecognized mechanisms fundamental to control body weight and fuel homeostasis. This book also discusses therapeutic utility of amylin as the first new medicine to treat diabetes since insulin. Provides a current comprehensive treatment of amylin the hormone Identifies the majority of amylin's physiologic functions
Advances in Pharmacology
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. - This volume includes reviews on some of the hottest topics in pharmacology, including: - Multidrug resistance and the MDR1 gene in gene therapy - Regulation of calcium channels in epithelial cells - Gene therapy and vascular disease - Potential therapeutic applications for Heparin - Calcium channel blockers - Antithrombotic agents - Regulation of potassium channels in epithelial cells
Clinical Trials Handbook
Best practices for conducting effective and safe clinical trials Clinical trials are arguably the most important steps in proving drug effectiveness and safety for public use. They require intensive planning and organization and involve a wide range of disciplines: data management, biostatistics, pharmacology, toxicology, modeling and simulation, regulatory monitoring, ethics, and particular issues for given disease areas. Clinical Trials Handbook provides a comprehensive and thorough reference on the basics and practices of clinical trials. With contributions from a range of international authors, the book takes the reader through each trial phase, technique, and issue. Chapters cover every...
HIV: Molecular Biology and Pathogenesis: Viral Mechanisms
The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, ...
Hormones and Signaling
Hormones and Signaling focuses on the mechanisms of gene regulation at the cellular level. It also describes the actions of hormones in modulating gene regulation and animal development. - Glococorticoid and mineralcorticoid signaling - Orphan nuclear receptors - Nuclear receptor coactivators - Cytokines and STAT signaling - Coordination of cAMP signaling events through PKA anchoring - G protein-coupled extracellular Ca2+ (Ca2+0)-sensing receptor (CaR) - Pancreatic islet development - Genetic analysis of androgen receptors in development and disease - Antioprogestin regulable gene switch for induction of gene expression in vivo - Steroid receptor knockout model
Cardiovascular Pharmacology: Heart and circulation
Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions. - Contains up-to-date reviews of the most important emerging cardiovascular therapies written by world leaders in the field
GABA
A great deal of progress has been made in defining GABA (gamma-aminobutyric acid) transmission in the brain. Volume 54 of the Advances in Pharmacology series has also provided new insights into fundamental features of neurotransmission in general, such as the importance of allosterism and coincident signaling in regulating receptor function and overall cellular activity. These studies have led to the design and development of new drugs and potential therapeutic agents. Given the successes achieved over the first 50 years of GABA research, it is certain the 6th decade will yield its share of surprising discoveries and new insights. Published in this volume are articles providing thoughts and ...
Contemporary Aspects of Biomedical Research
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental. - Articles written by leading investigators in the field - Informs and updates on all the latest developments
