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The Business of Precision Medicine
The Business of Precision Medicine: How to Create and Develop a Sustainable and Scalable Business in Precisions Medicine bridges knowledge gaps and brings true business advantage to those seeking to harness fresh opportunities in todays' global precision medicine landscape. Beginning with a basic overview of the precision medicine paradigm shift, this book provides in-depth case studies of companies, start-ups, and institutions of various kinds in the public and private sectors, demonstrating how they successfully adopted new genomic technologies and databases-including bioinformatics tools, genetic signatures and gene panels-to build robust and scalable businesses. The book's author, Dr. Co...
Perfect DNA
Anyone can have his or her genome analysed today. But no one is prepared for how to deal psychologically or emotionally with an 80% probability of early-onset Alzheimer's. Or breast cancer. Or autism. Would we plan children earlier? Would we avoid children? Will we now design our children? Would our relationships be tarnished? And, perhaps more poignantly, does having a healthier genome make us superior beings? Perfect DNA is a novel that uses Dr Manuel Corpas' own experiences and expertise as genome scientist to begin exploring some of these tremendously challenging issues. Perfect DNA is set in the mid 2030's. The main protagonist is John Malcolm, a forty-something average-joe accountant b...
Antioxidants and Antioxidant Enzymes in Higher Plants
This book provides an overview of antioxidants and antioxidant enzymes and their role in the mechanisms of signaling and cellular tolerance under stress in plant systems. Major reactive oxygen species (ROS)-scavenging/modulating enzymes include the superoxide dismutase (SOD) that dismutates O2 into H2O2, which is followed by the coordinated action of a set of enzymes including catalase (CAT), ascorbate peroxidase (APX), glutathione peroxidase (GPX) and peroxiredoxins (Prx) that remove H2O2. In addition to the ROS scavenging enzymes, a number of other enzymes are found in various subcellular compartments, which are involved in maintaining such redox homeostasis either by directly scavenging p...
Nitric Oxide and Hydrogen Peroxide Signaling in Higher Plants
This book describes nitric oxide (NO) and hydrogen peroxide (H2O2) functions in higher plants. Much progress has been made in the field of NO and H2O2 research regarding the various mechanisms and functions of these two molecules, particularly regarding stress tolerance and signaling processes, but there are still gaps to be filled. NO and H2O2 are both crucial regulators of development, and act as signaling molecules at each step of the plant lifecycle, while also playing important roles in biotic and abiotic responses to environmental cues. The book summarizes key advances in the field of NO and H2O2 research, focusing on a range of processes including: signaling, metabolism, seed germination, development, sexual reproduction, fruit ripening, and defense.
Data Integration in the Life Sciences
This book constitutes the refereed proceedings of the 5th International Workshop on Data Integration in the Life Sciences, DILS 2008, held in Evry, France in June 2008. The 18 revised full papers presented together with 3 keynote talks and a tutorial paper were carefully reviewed and selected from 54 submissions. The papers adress all current issues in data integration and data management from the life science point of view and are organized in topical sections on Semantic Web for the life sciences, designing and evaluating architectures to integrate biological data, new architectures and experience on using systems, systems using technologies from the Semantic Web for the life sciences, mining integrated biological data, and new features of major resources for biomolecular data.
Computational Phraseology
Whether you wish to deliver on a promise, take a walk down memory lane or even on the wild side, phraseological units (also often referred to as phrasemes or multiword expressions) are present in most communicative situations and in all world’s languages. Phraseology, the study of phraseological units, has therefore become a rare unifying theme across linguistic theories. In recent years, an increasing number of studies have been concerned with the computational treatment of multiword expressions: these pertain among others to their automatic identification, extraction or translation, and to the role they play in various Natural Language Processing applications. Computational Phraseology is a comparatively new field where better understanding and more advances are urgently needed. This book aims to address this pressing need, by bringing together contributions focusing on different perspectives of this promising interdisciplinary field.
Computational and Corpus-based Phraseology
This book constitutes the refereed proceedings of the Third International Conference on Computational and Corpus-Based Phraseology, Europhras 2019, held in Malaga, Spain, in September 2019. The 31 full papers presented in this book were carefully reviewed and selected from 116 submissions. The papers in this volume cover a number of topics including general corpus-based approaches to phraseology, phraseology in translation and cross-linguistic studies, phraseology in language teaching and learning, phraseology in specialized languages, phraseology in lexicography, cognitive approaches to phraseology, the computational treatment of multiword expressions, and the development, annotation, and exploitation of corpora for phraseological studies. --
Baseball Prospectus 2014
The bestselling annual baseball preview from the smartest analysts in the business Now in its 19th edition, the Baseball Prospectus annual shows once again how it became the industry leader: The 2014 edition includes key stat categories, more controversial player predictions, and the kind of wise, witty baseball commentary that makes this phone-book-thick tome worth reading cover to cover. Baseball Prospectus 2014 provides fantasy players and insiders alike with prescient PECOTA projections, which Sports Illustrated has called "perhaps the game's most accurate projection model." Still, stats are just numbers if you don't see the larger context, and Baseball Prospectus brings together an elit...
Baseball Prospectus 2013
The bestselling annual baseball preview from the smartest analysts in the business The essential guide to the 2013 baseball season is on deck now, and whether you're a fan or fantasy player?or both?you won't be properly informed without it. Baseball Prospectus 2013 brings together an elite group of analysts to provide the definitive look at the upcoming season in critical essays and commentary on the thirty teams, their managers, and more than sixty players and prospects from each team. Contains critical essays on each of the thirty teams and player comments for some sixty players for each of those teams Projects each player's stats for the coming season using the groundbreaking PECOTA projection system, which has been called "perhaps the game's most accurate projection model" (Sports Illustrated) From Baseball Prospectus, America's leading provider of statistical analysis for baseball Now in its eighteenth edition, this New York Times bestselling insider's guide remains hands down the most authoritative and entertaining book of its kind.
