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1: Classification of Diabetes Mellitus: Criteria for Diagnosis. -- 2: The General Epidemiology of Type 2 Diabetes Mellitus. --New Insights on Prediabetes. -- 3: Vascular Reactivity in Diabetes Mellitus. -- 4: The Molecular and Genetic Basis of Type 2 Diabetes Mellitus. -- 5: Gene-Environment Interactions Predisposing to Type 2 Diabetes Mellitus. -- 6: Regulation of homeostasis: Glucose and other Substrates. -- 7: From Insulin Action to hormonal Resistance. --Old to Recent Molecular Mechanisms. -- 8: Type 2 Diabetes: Insulin Resistance vs. --Beta-Cell Defect. -- 9: Natural history of Type 2 Diabetes and Macrovascular Disease. -- 10: Microvascular Complications in Type 2 Diabetes. -- 11: Diabetic Neuropathy and Foot Disease. -- 12: Hypertension in Type 2 Diabetes Mellitus. -- 13: Dyslipidemia in Type 2 Diabetes Mellitus. -- 14: Diabetes Mellitus Prevention. -- 15: Present Recommendations in Type 2 Diabetes Mellitus Treatment. -- 16: New Pharmacological Approaches in Type 2 Diabetes Mellitus. -- 17: Relevant Outcomes in Type 2 Diabetes.
El síndrome metabólico es uno de los retos más intrigantes y fascinantes de la medicina contemporánea. Se trata de una patología en la que confluyen problemas de distintas áreas de la medicina: diferentes grados de hipertensión, acumulación de grasa, insulinoresistencia, estados protrombótico y proinflamatorio, todos juntos en la misma persona. Esta concurrencia de factores hace que la persona tenga un riesgo mucho mayor de sufrir enfermedad cardiovascular o diabetes mellitus tipo 2, que lo que la suma de los factores individuales supondría. Se trata de una "enfermedad" nueva, que ha llegado a ser un problema de salud pública muy importante en las sociedades desarrolladas y cuya r...
Humanity is aging. In the last century, life expectancy has increased by as much as 25 years, the greatest increase in 5’000 years of history. As a consequence the elderly constitute today the fastest growing segment of the world’s population. This new situation creates many social problems and challenges to health care which both the developed as well as the developing countries will have to cope with. The present publication shows that scientific progress has reached a level where nutritional interventions may play a decisive part in the prevention of degenerative conditions of age, improvement of quality of life and impact on health care burden and resources. Topics deal with such dif...
Health problems such as hypertension, tendency to diabetes, obesity, blood lipids, vascular disease, bone health, behaviour and learning and longevity may be ‘imprinted’ during early life. This process is defined as ‘programming’ whereby a nutritional stimulus operating at a critical, sensitive period of pre and postnatal life imprints permanent effects on the structure, physiology and metabolism. For this reason, academics and industry set-up the EC supported Scientific Workshop -Early Nutrition and its Later Consequences: New Opportunities. The prime objective of the Workshop was to generate a sound exchange of the latest scientific developments within the field of early nutrition to look for opportunities for new preventive health concepts. Further, a closer look was taken at the development of food applications which could provide (future) mothers and infants with improved nutrition that will ultimately lead to better future health. The Workshop was organised by the Dept. of Pediatrics, University of Munich, Germany in collaboration with the Danone Institutes and the Infant Nutrition Cluster, a collaboration of three large research projects funded by the EU.
First multi-year cumulation covers six years: 1965-70.
The incidence of insulin-dependent diabetes mellitus (100M) varies dramatically across racial groups and countries, with annual age-adjusted rates of approximately 40/100,000 per year in Finland, but only 0.51100,000 per year in China. Although reasons for these marked geographic differences are unknown, it is likely that genetic variations across populations play a m~or role. To determine the contribution of genetic factors to the global patterns of 100M incidence, international comparative studies are now being undertaken as part of the WHO Multinational Project for Childhood Oiabetes, known as the DIAMOND Project. It is, therefore, necessary to develop and implement epidemiologic standard...
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SECTION I. GENERAL ASPECTS: CHAPTER 1. Leptin and the Regulation of Body Weight. -- CHAPTER 2. Obesity: A Modern Pandemic. CHAPTER 3. Developmental Origins of Childhood Obesity: Potential Public Health Impact. -- CHAPTER 4. Genetics of Obesity: Are Genetic Differences Contributing to the Obesity Epidemic? -- CHAPTER 5. Social, Demographic, and Economic Status Factors and Obesity: A Global Perspective. -- CHAPTER 6. The Adipose Tissue: From a Passive Fat Depot to an Active Endocrine Organ. -- CHAPTER 7. Endocrine Regulation of Energy Homeostasis: Implications for Obesity and Diabetes. -- SECTION II PHYSIOPATHOLOGY: CHAPTER 8. Gene-Diet Interactions and Obesity. -- CHAPTER 9. Neuroendocrine Re...