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Single molecule tools have begun to revolutionize the molecular sciences, from biophysics to chemistry to cell biology. They hold the promise to be able to directly observe previously unseen molecular heterogeneities, quantitatively dissect complex reaction kinetics, ultimately miniaturize enzyme assays, image components of spatially distributed samples, probe the mechanical properties of single molecules in their native environment, and "just look at the thing" as anticipated by the visionary Richard Feynman already half a century ago. Single Molecule Tools, Part A: Fluorescence Based Approaches captures a snapshot of this vibrant, rapidly expanding field, presenting articles from pioneers in the field intended to guide both the newcomer and the expert through the intricacies of getting single molecule tools. - Includes time-tested core methods and new innovations applicable to any researcher employing single molecule tools - Methods included are useful to both established researchers and newcomers to the field - Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines
Utah has long claimed to have the greatest snow on Earth—the state itself has even trademarked the phrase. In Secrets of the Greatest Snow on Earth, Jim Steenburgh investigates Wasatch weather, exposing the myths, explaining the reality, and revealing how and why Utah’s powder lives up to its reputation. Steenburgh also examines ski and snowboard regions beyond Utah, providing a meteorological guide to mountain weather and snow climates around the world. Chapters explore mountain weather, avalanches and snow safety, historical accounts of weather events and snow conditions, and the basics of climate and weather forecasting. In this second edition, Steenburgh explains what creates the bes...
An interdisciplinary research unit consisting of 30 teams in the natural, economic and social sciences analyzed biodiversity and ecosystem services of a mountain rainforest ecosystem in the hotspot of the tropical Andes, with special reference to past, current and future environmental changes. The group assessed ecosystem services using data from ecological field and scenario-driven model experiments, and with the help of comparative field surveys of the natural forest and its anthropogenic replacement system for agriculture. The book offers insights into the impacts of environmental change on various service categories mentioned in the Millennium Ecosystem Assessment (2005): cultural, regul...
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The remarkable story of how humankind discovered gravitational waves, chronicled with unparalleled historical and scientific vision. In 2016, the LIGO and Virgo Collaborations made headlines when they announced the detection of gravitational waves—a century after Albert Einstein first predicted their existence with his general theory of relativity. With unprecedented perspective as physicists at the forefront of this discovery, Mario Díaz, Gabriela González, and Jorge Pullin provide a comprehensive and accessible account of the quest to find gravitational waves, their controversial history, and the efforts that culminated with their detection and a Nobel Prize in Physics. The Sounds of t...