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Cancer-Associated Defects in the DNA Damage Response: Drivers for Malignant Transformation and Potential Therapeutic Targets
For this eBook, and the associated Research Topic in Frontiers in Genetics, entitled: ‘Cancer-associated defects in the DNA damage response: drivers for malignant transformation and potential therapeutic targets’ we have selected 10 papers that each discusses important, yet distinct aspects of the response to DNA damage in normal cells and cancer cells. Using an evolutionary conserved signaling network called the ‘DNA damage response (DDR)’ cells maintain the integrity of their genome, and thus safeguard cellular functioning and the ability to create viably progeny. Initially, the DDR appeared to consist of few linear kinase-driven pathways. However, research over the past decades in...
Legal Theory, Sources of Law and the Semantic Web
Attempts to construct an integrated conceptual framework for the application-neutral and problem-neutral representation of sources of law using Semantic Web technology and concepts and some technically straightforward extensions to Semantic Web technology based on established practices found in fielded applications.
How Leaders Mobilize Workers
This book combines a thorough analysis of class politics in twenty countries between 1863 and 1919 with a general theory of political mobilization focusing on individual leadership. It explains why leaders chose social democracy, revolution, or moderate syndicalism to mobilize workers, and shows what lasting consequences their choices produced.
The Social Question in the Twenty-First Century
At publication date, a free ebook version of this title will be available through Luminos, University of California Press’s Open Access publishing program. Visit www.luminosoa.org to learn more. Want. Disease. Ignorance. Squalor. Idleness. Taken together, these comprise the “giant evils” expressed in the Social Question—first raised in mid-nineteenth-century Europe to diagnose the crises produced by the emergence of the industrial society. Due to a globalized switch to neoliberalism in the final quarter of the twentieth century, the Social Question has made a worldwide comeback. The Social Question in the Twenty-First Century maps out the linked crises across regions and countries an...
Enlightened Self-Interest
"In the face of entrenched politics in a polarized society, ineffective economic policy in an unequal society, and environmental inaction in a world that is burning, many well-intentioned people are left feeling helpless, dispirited, and most importantly, apathetic, before an immovable force. They recognize the need for structural, legislative, and policy changes to address the legacy of slavery and deeply rooted inequality in the United States in particular, but they still may yearn to do something as individuals to promote change in these areas. What changes can individuals make in their personal lives that could foster a more civil, equitable, and sustainable society? Recovering lawyer an...
Assessment and Treatment of Sarcopenia and Frailty in the Setting of Personalized Internal Medicine
The recognition and implementation of personalized internal medicine is of the utmost importance for physicians, nurses, dieticians and other healthcare professionals engaged in clinics. The assessment of sarcopenia and frailty, in middle-aged patients, as an embodiment of treatment personalization, is essential in settings of acute and chronic disease, both in the hospital and in ambulatory settings. This book describes various practical tools for the assessment of sarcopenia and frailty, reviews relevant findings from the current professional literature, and suggests treatment modifications for frail patients.
Dynamics of Leadership in Public Se
Eminently readible, current, and comprhensive, this acclaimed text sets the standard for instruction in
