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Surface Architecture of Fungal Pathogens
Surface components in fungal cells include cell wall molecules and, in certain cases, capsular structures. In pathogens, these components are responsible for key events during interaction with the host. These events include recognition of pathogens by the immune system and generation of damage to host cells and tissues. The molecular nature of surface structures in fungi is vast and may include (glyco)proteins, polysaccharides, lipids and pigments. Many of them have been strictly associated with the antifungal immune response, as well as with steps of fungal adhesion and dissemination during interaction with host cells. For many fungal pathogens, surface composition and architecture are determinant for either disease progression or control. The diversity of the composition of the cell surface and its molecular architecture are believed to include targets for the action of new antifungals, as well as immunogens with potential to interfere with fungal diseases in favor of the host.
Vaccines and immunotherapy against fungi: the new frontier
Invasive fungal diseases have increased many fold over the past 50 years. Current treatment regimens typically require prolonged administration of antifungal medications that can have significant toxicity. Moreover, our present potent antifungal armamentarium fails to eradicate fungal pathogens from certain compromised hosts. Additionally, invasive fungal diseases continue to have unacceptably high mortality rates. A growing body of work has focused on the utility of vaccines and/or immunotherapy as a powerful tool in combating mycoses, either for the active treatment, as an adjuvant, or in the prevention of specific fungal pathogens. This Research Topic will detail the exciting progress in developing vaccines and immunotherapy for fungi.
Becoming Brazil
When Dom Pedro I declared Brazilian independence in September 1822, he could not have known that the newly liberated country would one day become a nation of 200 million citizens. Becoming Brazil: New Fiction, Poetry, and Memoir presents writing by and about the vibrant people of this fascinatingly diverse and rapidly changing country. Although Brazil is by far the largest and most populous nation in South America—with approximately the same landmass as the US—Brazilian literature, art, and culture are little known in countries where Portuguese is not spoken. But within Brazil, contemporary artists and writers are creating a culture that is both cosmopolitan and inclusive of the nation’s diverse regions, customs, and dialects. Becoming Brazil includes works by canonical twentieth-century Brazilian writers, innovative contemporary authors, and new voices, many of them in translation for the first time. The volume also includes stunning black and white images by Brazilian photographer Sebastião Salgado.
Sample Preparation in LC-MS Bioanalysis
Revised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis Following in the footsteps of the previously published Handbook of LC-MS Bioanalysis, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass Spectrometry (LC-MS) bioanalysis of small and large molecules. LC-MS bioanalysis is a key element of pharmaceutical research and development, post-approval therapeutic drug monitoring, and many other studies used in human healthcare. While advances are continually being made in key aspects of LC-MS bioanalysis such as sensitiv...
The Science of Curling
Boris Seidl is a sports teacher and international Curling coach. His book deals with the Science of Curling - technical, physical and practical aspects, with a special focus on youth development. Since summer of 2022, he has been working as a national Curling coach for Brazil, where he has also educated two coaches and ice makers in Sao Paulo. In his new book, he has also included aspects of Wheelchair Curling. The methodology consisted of a literature review, exploratory interviews and an experiment to determine whether pulse rate and accuracy correlate. As a teacher and coach, he focused on youth development. He tried to give an overview of the current situation in Curling. This publication illustrates the potential for improvement, taking into account the sport motor aspects. This book is suitable for coaches, clubs, associations and athletes who want to improve in Curling as a competitive sport.
Temporary Anchorage Devices in Orthodontics E-Book
Achieve excellent patient outcomes with minimally invasive, cost-effective procedures! Temporary Anchorage Devices in Orthodontics, 2nd Edition covers everything you need to know to begin offering TADs in your practice. More than 1,500 full-color photos and illustrations guide you through the entire treatment process, from diagnosis and planning to biomechanics, implants and anchorage devices, and management of problems. Detailed case reports provide insight into the treatment of specific conditions. From a team of expert contributors led by Ravindra Nanda, this book shows the temporary anchorage techniques that will take your orthodontic skills to the next level. - Over 1,500 full-color cli...
Banzeiro Òkòtó
A confrontation with the destruction of the Amazon by a writer who moved her life into the heart of the forest.In lyrical, impassioned prose, Eliane Brum recounts her move from S&ã o Paulo to Altamira, a city along the Xingu River that has been devastated by the construction of one of the largest dams in the world. In community with the human and more-than-human world of the Amazon, Brum seeks to &‘ reforest' herself while building relationships with forest peoples who carry both the scars and the resistance of the forest in their bodies. Weaving together the lived stories of the region and its history of violent corruption and destruction, Banzeiro &Ò k&Ò t&ó is a call for radical cha...
Tribology of Machine Elements
Tribology is a branch of science that deals with machine elements and their friction, wear, and lubrication. Tribology of Machine Elements - Fundamentals and Applications presents the fundamentals of tribology, with chapters on its applications in engines, metal forming, seals, blasting, sintering, laser texture, biomaterials, and grinding.
Glycan Diversity in Fungi, Bacteria and Sea Organisms
The cell surface of fungi, bacteria and sea organisms is highly glycosylated. These glycans are oligo- or polysaccharide molecules that can be secreted or attached to protein or lipids forming glycoconjugates. They present extraordinary structural diversity that could explain their involvement in many fundamental cellular processes, including growth, differentiation and morphogenesis. Considerable advances have been made on the structural elucidation of these glycans. Their primary structures were determined based on a combination of mass spectrometry and NMR spectroscopy techniques. The combination of these sensitive and powerful techniques has allowed us to increase our structural knowledge of a wide variety of glycans expressed by different fungi, bacteria and sea organisms.
ALTERNATIVE FORMS OF KNOWING (IN) MATHEMATICS
This book grew out of a public lecture series, Alternative forms of knowledge construction in mathematics, conceived and organized by the first editor, and held annually at Portland State University from 2006. Starting from the position that mathematics is a human construction, implying that it cannot be separated from its historical, cultural, social, and political contexts, the purpose of these lectures was to provide a public intellectual space to interrogate conceptions of mathematics and mathematics education, particularly by looking at mathematical practices that are not considered relevant to mainstream mathematics education. One of the main thrusts was to contemplate the fundamental ...
