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Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self–microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, ...
An ideal design is site-specific, which is the only way architecture can create or connect with a specific sense of identity. This requires addressing the structural and local circumstances. This method handbook offers a playful way in which to systematically ascertain a complex framework and use it for your own design. The "9 x 9 method" takes all relevant factors and their alternate interaction into consideration: location, structure, shell, program, and materiality, all which, in a matrix with various intersections, produce exactly 9 "fields of action" for the design. The individual "fields" are not only illustrated visually with meaningful and eidetic pictures, but are also discussed in texts by leading specialists. For this book, the "9 x 9 method" was completely re-worked and redesigned. Authors: Florian Aicher, Jia Beisi, Adam Caruso, Dietmar Eberle, Franziska Hauser, Vittorio Magnago Lampugnani, Michele Lanza, Arno Lederer, Silvain Malfroy, Adrian Meyer, Marcello Nasso, Fritz Neumeyer, András Pálffy, Miroslav Šik, Laurent Stalder, Eberhard Tröger.
Captures the full scope of the literature, integrating ecological and molecular mechanisms that enable insects to enter a dormant state.
Nanotechnology has developed remarkably in recent years and, applied in the food industry, has allowed new industrial advances, the improvement of conventional technologies, and the commercialization of products with new features and functionalities. This progress offers the potential to increase productivity for producers, food security for consumers and economic growth for industries. Food Applications of Nanotechnology presents the main advances of nanotechnology for food industry development. The fundamental concepts of the technique are presented, followed by examples of application in several sectors, such as the enhancement of flavor, color and sensory characteristics; the description...
Structure, Bonding, and Reactivity of Reactant Complexes and Key Intermediates, by Elena Soriano and José Marco-Contelles.- Cycloisomerization of 1,n-Enynes Via Carbophilic Activation, by Patrick Yves Toullec and Véronique Michelet.- DFT-Based Mechanistic Insights into Noble Metal-Catalyzed Rearrangement of Propargylic Derivatives: Chirality Transfer Processes, by Olalla Nieto Faza and Angel R. de Lera.- N-Heterocyclic Carbene Complexes of Au, Pd, and Pt as Effective Catalysts in Organic Synthesis, by Andrea Correa, Steven P. Nolan and Luigi Cavallo.- Activation of Allenes by Gold Complexes: A Theoretical Standpoint, by Max Malacria, Louis Fensterbank and Vincent Gandon.- Heterocyclization of Allenes Catalyzed by Late Transition Metals: Mechanisms and Regioselectivity, by Benito Alcaide, Pedro Almendros, Teresa Martínez del Campo, Elena Soriano and José Marco-Contelles.- Gold-Catalyzed Cycloadditions Involving Allenes: Mechanistic Insights from Theoretical Studies, by Sergi Montserrat, Gregori Ujaque, Fernando López, José L. Mascareñas and Agustí Lledós.-
The latest volume in this series for organic chemists in industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.