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Parasite, Compartments, and Molecules
Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic to Latin America, standing out as a socio-economic problem for low-income tropical populations. Such disease affects millions of people worldwide and emerges in nonendemic areas due to migration and climate changes. The current chemotherapy is restricted to two nitroderivatives (benznidazole and nifurtimox), which is unsatisfactory due to limited efficacy (particularly in chronic phase) and adverse side effects. T. cruzi life cycle is complex, including invertebrate and vertebrate hosts and three developmental forms (epimastigotes, trypomastigotes, and amastigotes). In this chapter, we will discuss promising cellular and m...
Translational Research on Chagas Disease
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major neglected disease endemic to Latin America, associated to significant morbimortality comprising a remarkable socioeconomic problem mainly for low-income tropical populations. The present chapter focuses translational research on Chagas disease, approaching drug combinations and repositioning, particularly exploiting the parasite oxidative stress by prospecting prooxidant compounds combined with antagonists of antioxidant systems, for developing low-cost and safe therapies for this infection. The pertinent literature on protozoal parasitic diseases is reviewed as well as on repurposing disulfiram aiming the combination with...
Parasitology
Produced amidst the still rippling effects of a pandemic and as the world experiences the increasing burden of global warming and a rapidly changing biosphere, the second edition of Parasitology: A Conceptual Approach offers a timely overview of the eukaryotic parasites affecting human health and the health of domestic and wild animals and plants. The book offers a broadly encompassing, integrative view of the phenomenon of parasitism and of the remarkable diversity of the world’s parasites. This second edition has been thoroughly updated on all aspects of parasitism, including expanded sections on parasite biodiversity, parasite genomes, the interface between parasitology and disease ecol...
Práxis no Ensino em Biociências e Saúde: Oficinas, Experimentos e Jogos
O livro Práxis no ensino em Biociências e Saúde: o¬ficinas, experimentos e jogos traz para o leitor uma série de experiências e perspectivas descritas por pesquisadores, colaboradores e alunos de pós-graduação do Instituto Oswaldo Cruz (Fiocruz), diretamente engajados na produção e difusão de conhecimento cientí¬fico. A obra é formada por 17 capítulos divididos entre oficinas, experimentos e jogos que poderão servir como inspiração e motivação para o uso de recursos lúdicos, práticos e experimentais como estratégias inovadoras para os ambientes formais e não-formais de educação. A obra tem início com variado menu com 7 deliciosos capítulos apresentando o¬ficinas...
Biology of Trypanosoma cruzi
Trypanosoma cruzi, an important zoonotic protozoan that causes Chagas disease, affects at least 8 million people in Latin America. Chagas disease is an important life-long infection in humans that can be divided into distinct clinical stages: the acute phase, where patient symptoms can vary from asymptomatic to severe; the indeterminate form, which is usually asymptomatic; and the chronic phase, where cardiomyopathy and/or digestive megasyndromes appear. In addition to its medical importance, T. cruzi is an interesting biological model for studying processes such as: (1) cell differentiation, where a non-infective stage transforms into an infective one; (2) cell invasion, where the infective...
Parasitology
Parasitology: A Conceptual Approach focuses on the conceptual basis of parasitology, with the goal of providing students with an enriched view of parasites and their biology. Concentrating on concepts will enable readers to gain a broader perspective that will increase their ability to think critically about all kinds of parasitic associations. The interfaces between the study of parasitism and prominent biological disciplines such as biodiversity, immunology, ecology, evolution, conservation biology, and disease control are highlighted. Studying individual parasites is an essential part of parasitology so Parasitology: A Conceptual Approach contains an appendix which provides a concise overview of the biology of important human and veterinary parasites. End-of-chapter questions are provided, as is an instructor manual.
Environmental Guilt and Shame
Introduction -- Evidence of environmental guilt and shame -- Typology of guilt and shame -- Philosophical arguments for individuals, memberships, and collectives in states of guilt or shame -- Environmental guilt and shame -- Responding to critics of emotions and collectives -- Ethics of environmental guilt and shame -- The ethics of inducing and responding to guilt and shame -- Ritual responses to environmental guilt and shame -- Epilogue. Looking back, looking forward : lessons from studying environmental guilt and shame.
Microbial Stress: From Sensing to Intracellular and Population Responses
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Formação dos Profissionais da Educação, Experimentação e Inovação em Tempos de Transição nas Políticas Públicas
As políticas públicas de Educação passaram por profundas mudanças nas últimas décadas, como processo de democratização no Brasil, a promulgação da Constituição Cidadã em 1988 e da Lei de Diretrizes e Bases da Educação Nacional em 1996. Mas essas mudanças se aceleraram especialmente apartirde 2007 com a criação do fundeb, da Lei do Piso Salarial Nacional, do Plano Nacional de Formaçãode Professores em 2009 e como fim da desvinculação de receitas da União da Educação, momento em que o investimento em Educação aumentou significativamente. Em 2014 chegamos a um momento histórico que foia promulgação do Plano Nacional de Educação de 2014 a 2024, que marcou uma rev...
